Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus
Introduction: Diabetes mellitus type 2 has become a global health-care problem of modern society due to a pronounced increase of prevalence to pandemic proportions and vascular complications. At present, glycated hemoglobin (HbA1c) is widely accepted as a measure of glycemic control in established...
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doaj-3e154d290ad749719e17fb368003a53e2020-11-24T21:55:27ZengUniversity of SarajevoJournal of Health Sciences 2232-75761986-80492018-09-018210.17532/jhsci.2018.488Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitusEmina Panjeta0Radivoj Jadrić1Mirsad Panjeta2Jozo Ćorić3Amela Dervišević4Department of Biochemistry, Faculty of Pharmacy, University of Sarajevo, Bosnia and HerzegovinaDepartment of Human Physiology, Faculty of Medicine, University of Sarajevo, Bosnia and HerzegovinaClinical Center University in Sarajevo, Institute for Clinical Chemistry and Biochemistry and Department of Laboratory Sciences, Faculty of Health Sciences, University of Sarajevo, Sarajevo, Bosnia and HerzegovinaClinical Center University in Sarajevo, Institute for Clinical Chemistry and Biochemistry, Bosnia and HerzegovinaDepartment of Human Physiology, Faculty of Medicine, University of Sarajevo, Bosnia and Herzegovina Introduction: Diabetes mellitus type 2 has become a global health-care problem of modern society due to a pronounced increase of prevalence to pandemic proportions and vascular complications. At present, glycated hemoglobin (HbA1c) is widely accepted as a measure of glycemic control in established diabetes. The aim of this study was to analyze the lipid profile in serum of patients with diabetes mellitus type 2, and its relationship with HbA1c levels. Methods: The observational cross-sectional study included 60 diabetic patients, 30 men, and 30 women, age 32–94 years. Patients were assigned into two groups based on HbA1c values; Group 1: HbA1c ≤ 7% (good glycemic control) and Group 2: HbA1c > 7% (poor glycemic control). We analyzed the concentration of glucose, HbA1c, and lipid profile including total cholesterol levels, triglycerides (TAG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL). Results: Significantly lower values of glucose concentration, TAG and the ratio TAG/HDLc were obtained in the group of patients with good glycemic control. (p < 0.0005) Patients with good glycemic control had lower values of Castelli 1 and Castelli 2 index, and atherogenic index of plasma, compared to patients with poor glycemic control, but this difference was not significant. (p > 0.005) Our study revealed a significant positive correlation between HbA1c and triglyceride level (r = 0.375; p = 0.003) and HbA1c and ratio triglyceride/HDLc (r = 0.335; p = 0.009). Conclusion: HbA1c can also be used as a predictor of dyslipidemia in type 2 diabetics in addition to as a glycemic control parameter. https://www.jhsci.ba/ojs/index.php/jhsci/article/view/641HDLlipid profilediabetes mellitus type 2DMT2HbA1cLDL |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Emina Panjeta Radivoj Jadrić Mirsad Panjeta Jozo Ćorić Amela Dervišević |
spellingShingle |
Emina Panjeta Radivoj Jadrić Mirsad Panjeta Jozo Ćorić Amela Dervišević Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus Journal of Health Sciences HDL lipid profile diabetes mellitus type 2 DMT2 HbA1c LDL |
author_facet |
Emina Panjeta Radivoj Jadrić Mirsad Panjeta Jozo Ćorić Amela Dervišević |
author_sort |
Emina Panjeta |
title |
Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus |
title_short |
Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus |
title_full |
Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus |
title_fullStr |
Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus |
title_full_unstemmed |
Correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus |
title_sort |
correlation of serum lipid profile and glycemic control parameters in patients with type 2 diabetes mellitus |
publisher |
University of Sarajevo |
series |
Journal of Health Sciences |
issn |
2232-7576 1986-8049 |
publishDate |
2018-09-01 |
description |
Introduction: Diabetes mellitus type 2 has become a global health-care problem of modern society due to a pronounced increase of prevalence to pandemic proportions and vascular complications. At present, glycated hemoglobin (HbA1c) is widely accepted as a measure of glycemic control in established diabetes. The aim of this study was to analyze the lipid profile in serum of patients with diabetes mellitus type 2, and its relationship with HbA1c levels.
Methods: The observational cross-sectional study included 60 diabetic patients, 30 men, and 30 women, age 32–94 years. Patients were assigned into two groups based on HbA1c values; Group 1: HbA1c ≤ 7% (good glycemic control) and Group 2: HbA1c > 7% (poor glycemic control). We analyzed the concentration of glucose, HbA1c, and lipid profile including total cholesterol levels, triglycerides (TAG), low-density lipoproteins (LDL), and high-density lipoproteins (HDL).
Results: Significantly lower values of glucose concentration, TAG and the ratio TAG/HDLc were obtained in the group of patients with good glycemic control. (p < 0.0005) Patients with good glycemic control had lower values of Castelli 1 and Castelli 2 index, and atherogenic index of plasma, compared to patients with poor glycemic control, but this difference was not significant. (p > 0.005) Our study revealed a significant positive correlation between HbA1c and triglyceride level (r = 0.375; p = 0.003) and HbA1c and ratio triglyceride/HDLc (r = 0.335; p = 0.009).
Conclusion: HbA1c can also be used as a predictor of dyslipidemia in type 2 diabetics in addition to as a glycemic control parameter.
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topic |
HDL lipid profile diabetes mellitus type 2 DMT2 HbA1c LDL |
url |
https://www.jhsci.ba/ojs/index.php/jhsci/article/view/641 |
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