Pan-cancer landscape of homologous recombination deficiency

Pan-cancer landscape of homologous recombination deficiency

Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest several cancer types that may benefit from PARP inhi...

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Main Authors: Luan Nguyen, John W. M. Martens, Arne Van Hoeck, Edwin Cuppen
Format: Article
Language:English
Published: Nature Publishing Group 2020-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-19406-4
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spelling doaj-3e18fff65acc4455b9f7724c9219a6472021-05-11T08:53:27ZengNature Publishing GroupNature Communications2041-17232020-11-0111111210.1038/s41467-020-19406-4Pan-cancer landscape of homologous recombination deficiencyLuan Nguyen0John W. M. Martens1Arne Van Hoeck2Edwin Cuppen3Center for Molecular Medicine and Oncode Institute, University Medical Center UtrechtDepartment of Medical Oncology, Erasmus MC Cancer institute, Erasmus University Medical CenterCenter for Molecular Medicine and Oncode Institute, University Medical Center UtrechtCenter for Molecular Medicine and Oncode Institute, University Medical Center UtrechtCancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest several cancer types that may benefit from PARP inhibitor treatment.https://doi.org/10.1038/s41467-020-19406-4
collection DOAJ
language English
format Article
sources DOAJ
author Luan Nguyen
John W. M. Martens
Arne Van Hoeck
Edwin Cuppen
spellingShingle Luan Nguyen
John W. M. Martens
Arne Van Hoeck
Edwin Cuppen
Pan-cancer landscape of homologous recombination deficiency
Nature Communications
author_facet Luan Nguyen
John W. M. Martens
Arne Van Hoeck
Edwin Cuppen
author_sort Luan Nguyen
title Pan-cancer landscape of homologous recombination deficiency
title_short Pan-cancer landscape of homologous recombination deficiency
title_full Pan-cancer landscape of homologous recombination deficiency
title_fullStr Pan-cancer landscape of homologous recombination deficiency
title_full_unstemmed Pan-cancer landscape of homologous recombination deficiency
title_sort pan-cancer landscape of homologous recombination deficiency
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2020-11-01
description Cancers deficient in homologous recombination can benefit from treatment with poly ADP-ribose polymerase (PARP) inhibitors. Here, the authors generated a classifier that can predict homologous recombination deficiency from genomic data and suggest several cancer types that may benefit from PARP inhibitor treatment.
url https://doi.org/10.1038/s41467-020-19406-4
work_keys_str_mv AT luannguyen pancancerlandscapeofhomologousrecombinationdeficiency
AT johnwmmartens pancancerlandscapeofhomologousrecombinationdeficiency
AT arnevanhoeck pancancerlandscapeofhomologousrecombinationdeficiency
AT edwincuppen pancancerlandscapeofhomologousrecombinationdeficiency
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