Can initial chest CT scan predict status and clinical outcomes of COVID-19 infection? A retrospective cohort study
Abstract Background We aimed to investigate the association of initial chest CT scan findings with status and adverse outcomes of COVID-19 (including ICU admission, mortality, and disease severity). This retrospective cohort study was performed in three hospitals in Babol, northern Iran, between Feb...
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doaj-3e1d50b7f05c4540848fc09223feb5bd2021-07-04T11:33:57ZengSpringerOpenThe Egyptian Journal of Radiology and Nuclear Medicine2090-47622021-06-0152111010.1186/s43055-021-00538-6Can initial chest CT scan predict status and clinical outcomes of COVID-19 infection? A retrospective cohort studyIman Abdollahi0Mehrdad Nabahati1Mostafa Javanian2Hoda Shirafkan3Rahele Mehraeen4Student Research Committee, Babol University of Medical SciencesDepartment of Radiology, Shahid Beheshti Hospital, Babol University of Medical SciencesInfectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical SciencesSocial Determinants of Health Research Center, Health Research Institute, Babol University of Medical SciencesDepartment of Radiology, Shahid Beheshti Hospital, Babol University of Medical SciencesAbstract Background We aimed to investigate the association of initial chest CT scan findings with status and adverse outcomes of COVID-19 (including ICU admission, mortality, and disease severity). This retrospective cohort study was performed in three hospitals in Babol, northern Iran, between February and March 2020. Cases were confirmed by real-time polymerase chain reaction (RT-PCR). Clinical and paraclinical data of the patients were collected from their medical records. CT severity score (CSS) was calculated by a senior radiologist. Disease severity was determined based on the World Health Organization criteria. Results In total, 742 patients were included, of whom 451 (60.8%) were males and 291 (39.2%) were females. The mean age was 56.59 ± 14.88 years old. Also, 523 (70.5%) were RT-PCR-positive. Ground glass opacity was directly associated with RT-PCR positivity (odds ratio [OR] = 2.07). Also, RT-PCR-positive cases had significantly a higher CSS than RT-PCR-negative cases (p = 0.037). In patients confirmed with COVID-19, peribronchovascular distribution of lesions, number of zones involved, and CSS were associated with increased risk of ICU admission (OR = 2.93, OR = 2.10, and OR = 1.14, respectively), mortality (OR = 2.30, OR = 1.35, and OR=1.08, respectively), severe disease (OR = 2.06, OR = 1.68, and OR = 1.10, respectively), and critical disease (OR = 4.62, OR = 3.21, and OR = 1.23, respectively). Also, patients who had consolidation were at a higher risk of severe disease compared with those who did not (OR = 4.94). Conclusion Initial chest CT scan can predict COVID-19 positivity, ICU admission, mortality, and disease severity, specifically through CSS.https://doi.org/10.1186/s43055-021-00538-6Computed tomographyCoronavirus disease 2019Clinical outcome |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Iman Abdollahi Mehrdad Nabahati Mostafa Javanian Hoda Shirafkan Rahele Mehraeen |
spellingShingle |
Iman Abdollahi Mehrdad Nabahati Mostafa Javanian Hoda Shirafkan Rahele Mehraeen Can initial chest CT scan predict status and clinical outcomes of COVID-19 infection? A retrospective cohort study The Egyptian Journal of Radiology and Nuclear Medicine Computed tomography Coronavirus disease 2019 Clinical outcome |
author_facet |
Iman Abdollahi Mehrdad Nabahati Mostafa Javanian Hoda Shirafkan Rahele Mehraeen |
author_sort |
Iman Abdollahi |
title |
Can initial chest CT scan predict status and clinical outcomes of COVID-19 infection? A retrospective cohort study |
title_short |
Can initial chest CT scan predict status and clinical outcomes of COVID-19 infection? A retrospective cohort study |
title_full |
Can initial chest CT scan predict status and clinical outcomes of COVID-19 infection? A retrospective cohort study |
title_fullStr |
Can initial chest CT scan predict status and clinical outcomes of COVID-19 infection? A retrospective cohort study |
title_full_unstemmed |
Can initial chest CT scan predict status and clinical outcomes of COVID-19 infection? A retrospective cohort study |
title_sort |
can initial chest ct scan predict status and clinical outcomes of covid-19 infection? a retrospective cohort study |
publisher |
SpringerOpen |
series |
The Egyptian Journal of Radiology and Nuclear Medicine |
issn |
2090-4762 |
publishDate |
2021-06-01 |
description |
Abstract Background We aimed to investigate the association of initial chest CT scan findings with status and adverse outcomes of COVID-19 (including ICU admission, mortality, and disease severity). This retrospective cohort study was performed in three hospitals in Babol, northern Iran, between February and March 2020. Cases were confirmed by real-time polymerase chain reaction (RT-PCR). Clinical and paraclinical data of the patients were collected from their medical records. CT severity score (CSS) was calculated by a senior radiologist. Disease severity was determined based on the World Health Organization criteria. Results In total, 742 patients were included, of whom 451 (60.8%) were males and 291 (39.2%) were females. The mean age was 56.59 ± 14.88 years old. Also, 523 (70.5%) were RT-PCR-positive. Ground glass opacity was directly associated with RT-PCR positivity (odds ratio [OR] = 2.07). Also, RT-PCR-positive cases had significantly a higher CSS than RT-PCR-negative cases (p = 0.037). In patients confirmed with COVID-19, peribronchovascular distribution of lesions, number of zones involved, and CSS were associated with increased risk of ICU admission (OR = 2.93, OR = 2.10, and OR = 1.14, respectively), mortality (OR = 2.30, OR = 1.35, and OR=1.08, respectively), severe disease (OR = 2.06, OR = 1.68, and OR = 1.10, respectively), and critical disease (OR = 4.62, OR = 3.21, and OR = 1.23, respectively). Also, patients who had consolidation were at a higher risk of severe disease compared with those who did not (OR = 4.94). Conclusion Initial chest CT scan can predict COVID-19 positivity, ICU admission, mortality, and disease severity, specifically through CSS. |
topic |
Computed tomography Coronavirus disease 2019 Clinical outcome |
url |
https://doi.org/10.1186/s43055-021-00538-6 |
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