A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome

A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome

Bacterial type III secretion systems (T3SS) play important roles in pathogenesis. Here, Diepoldet al. show the dynamic nature of complexes formed of essential T3SS components in live bacteria, and that extracellular calcium concentrations influence these cytosolic complexes likely via SctK/YscK.

Bibliographic Details
Main Authors: Andreas Diepold, Erdinc Sezgin, Miles Huseyin, Thomas Mortimer, Christian Eggeling, Judith P. Armitage
Format: Article
Language:English
Published: Nature Publishing Group 2017-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms15940
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spelling doaj-3e1f04d375c04aa3a541f55dd642d53b2021-05-11T07:37:31ZengNature Publishing GroupNature Communications2041-17232017-06-018111210.1038/ncomms15940A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisomeAndreas Diepold0Erdinc Sezgin1Miles Huseyin2Thomas Mortimer3Christian Eggeling4Judith P. Armitage5Department of Biochemistry, University of OxfordMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of OxfordDepartment of Biochemistry, University of OxfordDepartment of Biochemistry, University of OxfordMRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, University of OxfordDepartment of Biochemistry, University of OxfordBacterial type III secretion systems (T3SS) play important roles in pathogenesis. Here, Diepoldet al. show the dynamic nature of complexes formed of essential T3SS components in live bacteria, and that extracellular calcium concentrations influence these cytosolic complexes likely via SctK/YscK.https://doi.org/10.1038/ncomms15940
collection DOAJ
language English
format Article
sources DOAJ
author Andreas Diepold
Erdinc Sezgin
Miles Huseyin
Thomas Mortimer
Christian Eggeling
Judith P. Armitage
spellingShingle Andreas Diepold
Erdinc Sezgin
Miles Huseyin
Thomas Mortimer
Christian Eggeling
Judith P. Armitage
A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome
Nature Communications
author_facet Andreas Diepold
Erdinc Sezgin
Miles Huseyin
Thomas Mortimer
Christian Eggeling
Judith P. Armitage
author_sort Andreas Diepold
title A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome
title_short A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome
title_full A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome
title_fullStr A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome
title_full_unstemmed A dynamic and adaptive network of cytosolic interactions governs protein export by the T3SS injectisome
title_sort dynamic and adaptive network of cytosolic interactions governs protein export by the t3ss injectisome
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2017-06-01
description Bacterial type III secretion systems (T3SS) play important roles in pathogenesis. Here, Diepoldet al. show the dynamic nature of complexes formed of essential T3SS components in live bacteria, and that extracellular calcium concentrations influence these cytosolic complexes likely via SctK/YscK.
url https://doi.org/10.1038/ncomms15940
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