Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s disease
Introduction: The purpose of the study was to describe lipid profile and explore pathogenetic role of LDL-c on hypertension in patients with Cushing’s disease (CD). Hypertension is a common feature in patients with CD. Previous study found low-density lipoprotein cholesterol (LDL-c) uptake in vascul...
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doaj-3e28a4584fb24683872fd3d3618b8e442020-11-24T23:08:03ZengBioscientificaEndocrine Connections2049-36142049-36142018-04-017563764410.1530/EC-18-0010Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s diseaseLang Qin0Xiaoming Zhu1Xiaoxia Liu2Meifang Zeng3Ran Tao4Yan Zhuang5Yiting Zhou6Zhaoyun Zhang7Yehong Yang8Yiming Li9Yongfei Wang10Hongying Ye11Division of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pituitary Tumor Center, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaDivision of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Pituitary Tumor Center, Shanghai, ChinaDivision of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, ChinaIntroduction: The purpose of the study was to describe lipid profile and explore pathogenetic role of LDL-c on hypertension in patients with Cushing’s disease (CD). Hypertension is a common feature in patients with CD. Previous study found low-density lipoprotein cholesterol (LDL-c) uptake in vascular cells might be involved in vascular remodeling in patients with CD. Therefore, we evaluated the relationship between lipid profile and the blood pressure in patients with CD. Methods: This retrospective study included 84 patients referred to Huashan Hospital for the evaluation and diagnosis of CD from January 2012 to December 2013. All subjects had detailed clinical evaluation by the same group of endocrinology specialists to avoid subjective influences. Results: We found that high LDL-c patients had significant higher body mass index (BMI), systolic blood pressure (SBP), cholesterol (CHO), triglyceride (TG), and apolipoproteinB (apoB) (P < 0.05). An association was detected between SBP values and lipids profile including CHO, TG, LDL-c, apolipoproteinA (apoA), apoB and lipoprotein(a) (LP(a)). After adjustment for all covariates, the LDL-c remained positively associated with SBP. In patients with or without taking statins, patients with LDL-c ≥3.37 mmol/L had higher SBP than patients with LDL-c <3.37 mmol/L. Then, LDL-c was coded using restricted cubic splines (RCS) function with three knots located at the 5th, 50th and 95th percentiles of the distribution of LDL-c. Compared to individuals with 3.215 mmol/L of LDL-c, individuals with 4.0, 4.5 and 5.0 mmol/L of LDL-c had differences of 3.86, 8.53 and 14.11 mmHg in SBP, respectively. Conclusions: An independent association between LDL-c and SBP was found in patients with CD. We speculate that LDL-c may be a pathogenic factor for hypertension in those patients.http://www.endocrineconnections.com/content/7/5/637.fullCDmetabolismlipid profileadrenalblood pressure |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Lang Qin Xiaoming Zhu Xiaoxia Liu Meifang Zeng Ran Tao Yan Zhuang Yiting Zhou Zhaoyun Zhang Yehong Yang Yiming Li Yongfei Wang Hongying Ye |
spellingShingle |
Lang Qin Xiaoming Zhu Xiaoxia Liu Meifang Zeng Ran Tao Yan Zhuang Yiting Zhou Zhaoyun Zhang Yehong Yang Yiming Li Yongfei Wang Hongying Ye Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s disease Endocrine Connections CD metabolism lipid profile adrenal blood pressure |
author_facet |
Lang Qin Xiaoming Zhu Xiaoxia Liu Meifang Zeng Ran Tao Yan Zhuang Yiting Zhou Zhaoyun Zhang Yehong Yang Yiming Li Yongfei Wang Hongying Ye |
author_sort |
Lang Qin |
title |
Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s disease |
title_short |
Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s disease |
title_full |
Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s disease |
title_fullStr |
Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s disease |
title_full_unstemmed |
Evaluation of lipid profile and its relationship with blood pressure in patients with Cushing’s disease |
title_sort |
evaluation of lipid profile and its relationship with blood pressure in patients with cushing’s disease |
publisher |
Bioscientifica |
series |
Endocrine Connections |
issn |
2049-3614 2049-3614 |
publishDate |
2018-04-01 |
description |
Introduction: The purpose of the study was to describe lipid profile and explore pathogenetic role of LDL-c on hypertension in patients with Cushing’s disease (CD). Hypertension is a common feature in patients with CD. Previous study found low-density lipoprotein cholesterol (LDL-c) uptake in vascular cells might be involved in vascular remodeling in patients with CD. Therefore, we evaluated the relationship between lipid profile and the blood pressure in patients with CD.
Methods: This retrospective study included 84 patients referred to Huashan Hospital for the evaluation and diagnosis of CD from January 2012 to December 2013. All subjects had detailed clinical evaluation by the same group of endocrinology specialists to avoid subjective influences.
Results: We found that high LDL-c patients had significant higher body mass index (BMI), systolic blood pressure (SBP), cholesterol (CHO), triglyceride (TG), and apolipoproteinB (apoB) (P < 0.05). An association was detected between SBP values and lipids profile including CHO, TG, LDL-c, apolipoproteinA (apoA), apoB and lipoprotein(a) (LP(a)). After adjustment for all covariates, the LDL-c remained positively associated with SBP. In patients with or without taking statins, patients with LDL-c ≥3.37 mmol/L had higher SBP than patients with LDL-c <3.37 mmol/L. Then, LDL-c was coded using restricted cubic splines (RCS) function with three knots located at the 5th, 50th and 95th percentiles of the distribution of LDL-c. Compared to individuals with 3.215 mmol/L of LDL-c, individuals with 4.0, 4.5 and 5.0 mmol/L of LDL-c had differences of 3.86, 8.53 and 14.11 mmHg in SBP, respectively.
Conclusions: An independent association between LDL-c and SBP was found in patients with CD. We speculate that LDL-c may be a pathogenic factor for hypertension in those patients. |
topic |
CD metabolism lipid profile adrenal blood pressure |
url |
http://www.endocrineconnections.com/content/7/5/637.full |
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