Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn’s Disease: A Case Report

Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn’s Disease: A Case Report

Herpes simplex virus (HSV) hepatitis is an uncommon cause of fulminant hepatic failure, seen mostly in immunocompromised patients. Conventional treatment modalities for inflammatory bowel disease (IBD), such as steroids and azathioprine, have been known to cause HSV hepatitis. However, the reported...

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Main Authors: Kanika Goel, Mark Bunker, Anna Balog, Jan F Silverman
Format: Article
Language:English
Published: SAGE Publishing 2019-07-01
Series:Clinical Medicine Insights: Case Reports
Online Access:https://doi.org/10.1177/1179547619858979
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spelling doaj-3e4e45cbb0fe40148416014dd8f8a50d2020-11-25T02:48:07ZengSAGE PublishingClinical Medicine Insights: Case Reports1179-54762019-07-011210.1177/1179547619858979Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn’s Disease: A Case ReportKanika GoelMark BunkerAnna BalogJan F SilvermanHerpes simplex virus (HSV) hepatitis is an uncommon cause of fulminant hepatic failure, seen mostly in immunocompromised patients. Conventional treatment modalities for inflammatory bowel disease (IBD), such as steroids and azathioprine, have been known to cause HSV hepatitis. However, the reported incidence of HSV hepatitis in IBD patients undergoing tumor necrosis factor (TNF)-α inhibitor therapy is very rare. In this case report, we describe a rare case of fulminant HSV hepatitis that developed in a patient with Crohn’s disease after treatment with the TNF-α inhibitor, adalimumab.https://doi.org/10.1177/1179547619858979
collection DOAJ
language English
format Article
sources DOAJ
author Kanika Goel
Mark Bunker
Anna Balog
Jan F Silverman
spellingShingle Kanika Goel
Mark Bunker
Anna Balog
Jan F Silverman
Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn’s Disease: A Case Report
Clinical Medicine Insights: Case Reports
author_facet Kanika Goel
Mark Bunker
Anna Balog
Jan F Silverman
author_sort Kanika Goel
title Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn’s Disease: A Case Report
title_short Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn’s Disease: A Case Report
title_full Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn’s Disease: A Case Report
title_fullStr Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn’s Disease: A Case Report
title_full_unstemmed Fulminant Herpes Simplex Hepatitis Secondary to Adalimumab in Crohn’s Disease: A Case Report
title_sort fulminant herpes simplex hepatitis secondary to adalimumab in crohn’s disease: a case report
publisher SAGE Publishing
series Clinical Medicine Insights: Case Reports
issn 1179-5476
publishDate 2019-07-01
description Herpes simplex virus (HSV) hepatitis is an uncommon cause of fulminant hepatic failure, seen mostly in immunocompromised patients. Conventional treatment modalities for inflammatory bowel disease (IBD), such as steroids and azathioprine, have been known to cause HSV hepatitis. However, the reported incidence of HSV hepatitis in IBD patients undergoing tumor necrosis factor (TNF)-α inhibitor therapy is very rare. In this case report, we describe a rare case of fulminant HSV hepatitis that developed in a patient with Crohn’s disease after treatment with the TNF-α inhibitor, adalimumab.
url https://doi.org/10.1177/1179547619858979
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AT annabalog fulminantherpessimplexhepatitissecondarytoadalimumabincrohnsdiseaseacasereport
AT janfsilverman fulminantherpessimplexhepatitissecondarytoadalimumabincrohnsdiseaseacasereport
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