Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency

Disseminated Mycobacterium genavense Infection in Patient with Adult-Onset Immunodeficiency

We report a case of disseminated Mycobacterium genavense infection resulting from neutralizing anti–interferon-γ autoantibodies in the patient. We identified M. genavense targeting the hsp65 gene in an aspiration specimen of the lymph node. Adult-onset immunodeficiency caused by neutralizing anti–in...

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Bibliographic Details
Main Authors: Takanori Asakura, Ho Namkoong, Takuro Sakagami, Naoki Hasegawa, Kiyofumi Ohkusu, Akira Nakamura
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2017-07-01
Series:Emerging Infectious Diseases
Subjects:
Mycobacterium genavense
adult-onset immunodeficiency
bacteria
Tuberculosis and other mycobacteria
Japan
nontuberculous mycobacteria
Online Access:https://wwwnc.cdc.gov/eid/article/23/7/16-1677_article
Description
Summary:We report a case of disseminated Mycobacterium genavense infection resulting from neutralizing anti–interferon-γ autoantibodies in the patient. We identified M. genavense targeting the hsp65 gene in an aspiration specimen of the lymph node. Adult-onset immunodeficiency caused by neutralizing anti–interferon-γ autoantibodies, in addition to HIV infection, can lead to disseminated nontuberculous mycobacterial infection.
ISSN:1080-6040
1080-6059

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