Trace level quantification of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl genotoxic impurity in trazodone using LC–MS/MS
A selective and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for the quantitative determination of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl (CCP HCl) a process related impurity in trazodone. The method provided excellent sensitivity at a typical...
Main Authors: | , , , , , |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2019-11-01
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Series: | Arabian Journal of Chemistry |
Online Access: | http://www.sciencedirect.com/science/article/pii/S1878535214002184 |