Trace level quantification of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl genotoxic impurity in trazodone using LC–MS/MS

Trace level quantification of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl genotoxic impurity in trazodone using LC–MS/MS

A selective and sensitive liquid chromatography–tandem mass spectrometry (LC–MS/MS) method was developed for the quantitative determination of 1-(3-chloropropyl)-4-(3-chlorophenyl)piperazine HCl (CCP HCl) a process related impurity in trazodone. The method provided excellent sensitivity at a typical...

Full description

Bibliographic Details
Main Authors: Nandigam Venugopal, Ambavaram Vijaya Bhaskar Reddy, Gajulapalle Madhavi, Jafariah Jaafar, Vemula Madhavi, Kalluru Gangadhara Reddy
Format: Article
Language:English
Published: Elsevier 2019-11-01
Series:Arabian Journal of Chemistry
Online Access:http://www.sciencedirect.com/science/article/pii/S1878535214002184

Similar Items

Similar Items