Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device
The photopic negative response (PhNR) is a negative component of the photopic flash electroretinogram that follows the b-wave and is thought to arise from the retinal ganglion cells. Reduction in its amplitude in idiopathic intracranial hypertension (IIH) has been previously documented using formal...
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doaj-3e6c4f3f0f204dd8884656d92b9e00752021-05-31T23:58:28ZengMDPI AGLife2075-17292021-05-011143743710.3390/life11050437Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld DeviceAntony Raharja0Shaun M. Leo1Isabelle Chow2Mathura Indusegaran3Christopher J. Hammond4Omar A. Mahroo5Sui H. Wong6Medical Eye Unit, St Thomas’ Hospital, London SE1 7EH, UKInstitute of Ophthalmology, University College London, London EC1V 9EL, UKDepartment of Ophthalmology, Guys & St Thomas’ NHS Foundation Trust, London SE1 7EH, UKDepartment of Ophthalmology, Guys & St Thomas’ NHS Foundation Trust, London SE1 7EH, UKDepartment of Ophthalmology, Guys & St Thomas’ NHS Foundation Trust, London SE1 7EH, UKDepartment of Ophthalmology, Guys & St Thomas’ NHS Foundation Trust, London SE1 7EH, UKMedical Eye Unit, St Thomas’ Hospital, London SE1 7EH, UKThe photopic negative response (PhNR) is a negative component of the photopic flash electroretinogram that follows the b-wave and is thought to arise from the retinal ganglion cells. Reduction in its amplitude in idiopathic intracranial hypertension (IIH) has been previously documented using formal electroretinography. This study explored the use of a handheld device (RETeval, LKC technologies, Gaithersburg, MD, USA) in 72 IIH patients of varying stages and severity (and seven controls) and investigated associations between PhNR parameters and disease severity. PhNR amplitudes at 72 ms (P<sub>72</sub>) and p-ratio (ratio to b-wave peak value) differed significantly across groups, with a trend towards smaller amplitudes in those with severe IIH, defined as papilloedema with Modified Frisén Scale (MFS) ≥ 3, retinal nerve fibre layer (RNFL) ≥ 150 μm or atrophic papilloedema (<i>p</i> = 0.0048 and <i>p</i> = 0.018 for P72 and p-ratio, respectively). PhNR parameters did not correlate with MFS, RNFL thickness, standard automated perimetry mean deviation or macular ganglion cell layer volume. This study suggests that PhNR measurement using a handheld device is feasible and could potentially augment the assessment of disease severity in IIH. The clinical utility of PhNR monitoring in IIH patients requires further investigation.https://www.mdpi.com/2075-1729/11/5/437idiopathic intracranial hypertensionretinaelectroretinographyretinal ganglion cellspapilledemapseudotumor cerebri |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Antony Raharja Shaun M. Leo Isabelle Chow Mathura Indusegaran Christopher J. Hammond Omar A. Mahroo Sui H. Wong |
spellingShingle |
Antony Raharja Shaun M. Leo Isabelle Chow Mathura Indusegaran Christopher J. Hammond Omar A. Mahroo Sui H. Wong Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device Life idiopathic intracranial hypertension retina electroretinography retinal ganglion cells papilledema pseudotumor cerebri |
author_facet |
Antony Raharja Shaun M. Leo Isabelle Chow Mathura Indusegaran Christopher J. Hammond Omar A. Mahroo Sui H. Wong |
author_sort |
Antony Raharja |
title |
Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device |
title_short |
Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device |
title_full |
Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device |
title_fullStr |
Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device |
title_full_unstemmed |
Exploratory Study of the Association between the Severity of Idiopathic Intracranial Hypertension and Electroretinogram Photopic Negative Response Amplitude Obtained Using a Handheld Device |
title_sort |
exploratory study of the association between the severity of idiopathic intracranial hypertension and electroretinogram photopic negative response amplitude obtained using a handheld device |
publisher |
MDPI AG |
series |
Life |
issn |
2075-1729 |
publishDate |
2021-05-01 |
description |
The photopic negative response (PhNR) is a negative component of the photopic flash electroretinogram that follows the b-wave and is thought to arise from the retinal ganglion cells. Reduction in its amplitude in idiopathic intracranial hypertension (IIH) has been previously documented using formal electroretinography. This study explored the use of a handheld device (RETeval, LKC technologies, Gaithersburg, MD, USA) in 72 IIH patients of varying stages and severity (and seven controls) and investigated associations between PhNR parameters and disease severity. PhNR amplitudes at 72 ms (P<sub>72</sub>) and p-ratio (ratio to b-wave peak value) differed significantly across groups, with a trend towards smaller amplitudes in those with severe IIH, defined as papilloedema with Modified Frisén Scale (MFS) ≥ 3, retinal nerve fibre layer (RNFL) ≥ 150 μm or atrophic papilloedema (<i>p</i> = 0.0048 and <i>p</i> = 0.018 for P72 and p-ratio, respectively). PhNR parameters did not correlate with MFS, RNFL thickness, standard automated perimetry mean deviation or macular ganglion cell layer volume. This study suggests that PhNR measurement using a handheld device is feasible and could potentially augment the assessment of disease severity in IIH. The clinical utility of PhNR monitoring in IIH patients requires further investigation. |
topic |
idiopathic intracranial hypertension retina electroretinography retinal ganglion cells papilledema pseudotumor cerebri |
url |
https://www.mdpi.com/2075-1729/11/5/437 |
work_keys_str_mv |
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