VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion
Objective. To investigate the relationship among angiogenic cytokines, inflammatory markers, and fibrinolytic activity in tuberculous pleural effusion (TBPE) and their clinical importance. Methods. Forty-two patients diagnosed with TBPE were studied. Based on chest ultrasonography, there were 26 loc...
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doaj-3e70cc6fdad54e33abba6d5eaf568a652020-11-25T02:19:11ZengHindawi LimitedThe Scientific World Journal2356-61401537-744X2015-01-01201510.1155/2015/417124417124VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural EffusionMauo-Ying Bien0Ming-Ping Wu1Wei-Lin Chen2Chi-Li Chung3School of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, TaiwanDepartment of Obstetrics and Gynecology, Chi-Mei Medical Center, Tainan 710, TaiwanGraduate Institute of Medical Sciences and Department of Pharmacology, College of Medicine, Taipei Medical University, Taipei 110, TaiwanSchool of Respiratory Therapy, College of Medicine, Taipei Medical University, Taipei 110, TaiwanObjective. To investigate the relationship among angiogenic cytokines, inflammatory markers, and fibrinolytic activity in tuberculous pleural effusion (TBPE) and their clinical importance. Methods. Forty-two patients diagnosed with TBPE were studied. Based on chest ultrasonography, there were 26 loculated and 16 nonloculated TBPE patients. The effusion size radiological scores and effusion vascular endothelial growth factor (VEGF), interleukin- (IL-) 8, plasminogen activator inhibitor type-1 (PAI-1), and tissue type plasminogen activator (tPA) were measured. Treatment outcome and pleural fibrosis, defined as radiological residual pleural thickening (RPT), were assessed at 6-month follow-up. Results. The effusion size and effusion lactate dehydrogenase (LDH), VEGF, IL-8, PAI-1, and PAI-1/tPA ratio were significantly higher, while effusion glucose, pH value, and tPA were significantly lower, in loculated than in nonloculated TBPE. VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE. Patients with higher VEGF or greater effusion size were prone to develop RPT (n=14; VEGF, odds ratio 1.28, P=0.01; effusion size, odds ratio 1.01, P=0.02), and VEGF was an independent predictor of RPT in TBPE (receiver operating characteristic curve AUC=0.985, P<0.001). Conclusions. Effusion VEGF correlates with pleural inflammation and fibrosis and may be targeted for adjunct therapy for TBPE.http://dx.doi.org/10.1155/2015/417124 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mauo-Ying Bien Ming-Ping Wu Wei-Lin Chen Chi-Li Chung |
spellingShingle |
Mauo-Ying Bien Ming-Ping Wu Wei-Lin Chen Chi-Li Chung VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion The Scientific World Journal |
author_facet |
Mauo-Ying Bien Ming-Ping Wu Wei-Lin Chen Chi-Li Chung |
author_sort |
Mauo-Ying Bien |
title |
VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion |
title_short |
VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion |
title_full |
VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion |
title_fullStr |
VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion |
title_full_unstemmed |
VEGF Correlates with Inflammation and Fibrosis in Tuberculous Pleural Effusion |
title_sort |
vegf correlates with inflammation and fibrosis in tuberculous pleural effusion |
publisher |
Hindawi Limited |
series |
The Scientific World Journal |
issn |
2356-6140 1537-744X |
publishDate |
2015-01-01 |
description |
Objective. To investigate the relationship among angiogenic cytokines, inflammatory markers, and fibrinolytic activity in tuberculous pleural effusion (TBPE) and their clinical importance. Methods. Forty-two patients diagnosed with TBPE were studied. Based on chest ultrasonography, there were 26 loculated and 16 nonloculated TBPE patients. The effusion size radiological scores and effusion vascular endothelial growth factor (VEGF), interleukin- (IL-) 8, plasminogen activator inhibitor type-1 (PAI-1), and tissue type plasminogen activator (tPA) were measured. Treatment outcome and pleural fibrosis, defined as radiological residual pleural thickening (RPT), were assessed at 6-month follow-up.
Results. The effusion size and effusion lactate dehydrogenase (LDH), VEGF, IL-8, PAI-1, and PAI-1/tPA ratio were significantly higher, while effusion glucose, pH value, and tPA were significantly lower, in loculated than in nonloculated TBPE. VEGF and IL-8 correlated positively with LDH and PAI-1/tPA ratio and negatively with tPA in both loculated and nonloculated TBPE. Patients with higher VEGF or greater effusion size were prone to develop RPT (n=14; VEGF, odds ratio 1.28, P=0.01; effusion size, odds ratio 1.01, P=0.02), and VEGF was an independent predictor of RPT in TBPE (receiver operating characteristic curve AUC=0.985, P<0.001). Conclusions. Effusion VEGF correlates with pleural inflammation and fibrosis and may be targeted for adjunct therapy for TBPE. |
url |
http://dx.doi.org/10.1155/2015/417124 |
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