Incidence, Prevalence, and Clinical Epidemiology of Inflammatory Bowel Disease in the Arab World: A Systematic Review and Meta-Analysis
Objectives: Despite the recent findings of the rising incidence of inflammatory bowel disease (IBD) in Arab countries, there are limited data on the characteristics of IBD patients and the disease course in the Arab world. This systematic review aimed to investigate the incidence and epidemiology of...
Main Authors: | , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Karger Publishers
2021-09-01
|
Series: | Inflammatory Intestinal Diseases |
Subjects: | |
Online Access: | https://www.karger.com/Article/FullText/518003 |
id |
doaj-3e72af3e587e4ea5a530a2d047998832 |
---|---|
record_format |
Article |
spelling |
doaj-3e72af3e587e4ea5a530a2d0479988322021-09-30T08:12:31ZengKarger PublishersInflammatory Intestinal Diseases2296-94032296-93652021-09-016312313110.1159/000518003518003Incidence, Prevalence, and Clinical Epidemiology of Inflammatory Bowel Disease in the Arab World: A Systematic Review and Meta-AnalysisMahmoud Mosli0Sameer Alawadhi1Fuad Hasan2Antoine Abou Rached3Faisal Sanai4Silvio Danese5Gastroenterologist and Inflammatory Bowel Disease Specialist, King Abdulaziz University Hospital, Jeddah, Saudi ArabiaDigestive Disease Unit, Rashid Hospital, Dubai, United Arab EmiratesDepartment of Medicine, Faculty of Medicine, Kuwait University, Kuwait City, KuwaitSchool of Medicine, Lebanese University, Hadath, LebanonDepartment of Medicine, King Abdulaziz University, Jeddah, Saudi ArabiaProfessor of Gastroenterology, Faculty of Medicine, Humanitas University, Milan, ItalyObjectives: Despite the recent findings of the rising incidence of inflammatory bowel disease (IBD) in Arab countries, there are limited data on the characteristics of IBD patients and the disease course in the Arab world. This systematic review aimed to investigate the incidence and epidemiology of IBD in the Arab world. Material and Methods: We conducted a systematic literature review that utilized a comprehensive search of PubMed, Cochrane Central, SCOPUS, Google Scholar, and Web of Science from their inception till August 2020. We included cross-sectional, prospective, and retrospective studies that examined the prevalence and/or epidemiological characteristics of IBD in Arab countries. Results: A total of 16 studies that examined IBD in Saudi Arabia, Egypt, Kuwait, the United Arab Emirates, Bahrain, Lebanon, and Oman were included. Generally, the included studies covered the period from the early 1990s to the late 2010s. A total of 1,627 ulcerative colitis (UC) patients and 1,588 Crohn’s disease (CD) patients were included in this systematic review. The mean age at diagnosis ranged from 24.13 to 43.6 years in adult cases and from 4.5 to 16 years in pediatric cases. In most of the included studies, the majority of patients were male. The quantitative analysis revealed a pooled incidence rate of 2.33 (95% confidence interval [CI] 1.2–3.4) per 100,000 persons per year for UC in the Arab world. Likewise, the pooled incidence rate for CD in the Arab world was 1.46 (95% CI 1.03–1.89) per 100,000 persons per year. Conclusion: There is a growing incidence of IBD in the Arab world, while IBD patients from Arab countries may present with some different characteristics, compared to their counterparts in Europe.https://www.karger.com/Article/FullText/518003arab worldinflammatory bowel diseaseepidemiologyincidence |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Mahmoud Mosli Sameer Alawadhi Fuad Hasan Antoine Abou Rached Faisal Sanai Silvio Danese |
spellingShingle |
Mahmoud Mosli Sameer Alawadhi Fuad Hasan Antoine Abou Rached Faisal Sanai Silvio Danese Incidence, Prevalence, and Clinical Epidemiology of Inflammatory Bowel Disease in the Arab World: A Systematic Review and Meta-Analysis Inflammatory Intestinal Diseases arab world inflammatory bowel disease epidemiology incidence |
author_facet |
Mahmoud Mosli Sameer Alawadhi Fuad Hasan Antoine Abou Rached Faisal Sanai Silvio Danese |
author_sort |
Mahmoud Mosli |
title |
Incidence, Prevalence, and Clinical Epidemiology of Inflammatory Bowel Disease in the Arab World: A Systematic Review and Meta-Analysis |
title_short |
Incidence, Prevalence, and Clinical Epidemiology of Inflammatory Bowel Disease in the Arab World: A Systematic Review and Meta-Analysis |
title_full |
Incidence, Prevalence, and Clinical Epidemiology of Inflammatory Bowel Disease in the Arab World: A Systematic Review and Meta-Analysis |
title_fullStr |
Incidence, Prevalence, and Clinical Epidemiology of Inflammatory Bowel Disease in the Arab World: A Systematic Review and Meta-Analysis |
title_full_unstemmed |
Incidence, Prevalence, and Clinical Epidemiology of Inflammatory Bowel Disease in the Arab World: A Systematic Review and Meta-Analysis |
title_sort |
incidence, prevalence, and clinical epidemiology of inflammatory bowel disease in the arab world: a systematic review and meta-analysis |
publisher |
Karger Publishers |
series |
Inflammatory Intestinal Diseases |
issn |
2296-9403 2296-9365 |
publishDate |
2021-09-01 |
description |
Objectives: Despite the recent findings of the rising incidence of inflammatory bowel disease (IBD) in Arab countries, there are limited data on the characteristics of IBD patients and the disease course in the Arab world. This systematic review aimed to investigate the incidence and epidemiology of IBD in the Arab world. Material and Methods: We conducted a systematic literature review that utilized a comprehensive search of PubMed, Cochrane Central, SCOPUS, Google Scholar, and Web of Science from their inception till August 2020. We included cross-sectional, prospective, and retrospective studies that examined the prevalence and/or epidemiological characteristics of IBD in Arab countries. Results: A total of 16 studies that examined IBD in Saudi Arabia, Egypt, Kuwait, the United Arab Emirates, Bahrain, Lebanon, and Oman were included. Generally, the included studies covered the period from the early 1990s to the late 2010s. A total of 1,627 ulcerative colitis (UC) patients and 1,588 Crohn’s disease (CD) patients were included in this systematic review. The mean age at diagnosis ranged from 24.13 to 43.6 years in adult cases and from 4.5 to 16 years in pediatric cases. In most of the included studies, the majority of patients were male. The quantitative analysis revealed a pooled incidence rate of 2.33 (95% confidence interval [CI] 1.2–3.4) per 100,000 persons per year for UC in the Arab world. Likewise, the pooled incidence rate for CD in the Arab world was 1.46 (95% CI 1.03–1.89) per 100,000 persons per year. Conclusion: There is a growing incidence of IBD in the Arab world, while IBD patients from Arab countries may present with some different characteristics, compared to their counterparts in Europe. |
topic |
arab world inflammatory bowel disease epidemiology incidence |
url |
https://www.karger.com/Article/FullText/518003 |
work_keys_str_mv |
AT mahmoudmosli incidenceprevalenceandclinicalepidemiologyofinflammatoryboweldiseaseinthearabworldasystematicreviewandmetaanalysis AT sameeralawadhi incidenceprevalenceandclinicalepidemiologyofinflammatoryboweldiseaseinthearabworldasystematicreviewandmetaanalysis AT fuadhasan incidenceprevalenceandclinicalepidemiologyofinflammatoryboweldiseaseinthearabworldasystematicreviewandmetaanalysis AT antoineabourached incidenceprevalenceandclinicalepidemiologyofinflammatoryboweldiseaseinthearabworldasystematicreviewandmetaanalysis AT faisalsanai incidenceprevalenceandclinicalepidemiologyofinflammatoryboweldiseaseinthearabworldasystematicreviewandmetaanalysis AT silviodanese incidenceprevalenceandclinicalepidemiologyofinflammatoryboweldiseaseinthearabworldasystematicreviewandmetaanalysis |
_version_ |
1716863786395107328 |