Neuroinflammation in Alzheimer's disease wanes with age

<p>Abstract</p> <p>Background</p> <p>Inflammation is a prominent feature in Alzheimer's disease (AD). It has been proposed that aging has an effect on the function of inflammation in the brain, thereby contributing to the development of age-related diseases like AD...

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Main Authors: Hoozemans Jeroen JM, Rozemuller Annemieke JM, van Haastert Elise S, Eikelenboom Piet, van Gool Willem A
Format: Article
Language:English
Published: BMC 2011-12-01
Series:Journal of Neuroinflammation
Subjects:
Online Access:http://www.jneuroinflammation.com/content/8/1/171
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spelling doaj-3e7ac383fcaa431d81f63db2ce3b05982020-11-25T00:25:07ZengBMCJournal of Neuroinflammation1742-20942011-12-018117110.1186/1742-2094-8-171Neuroinflammation in Alzheimer's disease wanes with ageHoozemans Jeroen JMRozemuller Annemieke JMvan Haastert Elise SEikelenboom Pietvan Gool Willem A<p>Abstract</p> <p>Background</p> <p>Inflammation is a prominent feature in Alzheimer's disease (AD). It has been proposed that aging has an effect on the function of inflammation in the brain, thereby contributing to the development of age-related diseases like AD. However, the age-dependent relationship between inflammation and clinical phenotype of AD has never been investigated.</p> <p>Methods</p> <p>In this study we have analysed features of the neuroinflammatory response in clinically and pathologically confirmed AD and control cases in relation to age (range 52-97 years). The mid-temporal cortex of 19 controls and 19 AD cases was assessed for the occurrence of microglia and astrocytes by immunohistochemistry using antibodies directed against CD68 (KP1), HLA class II (CR3/43) and glial fibrillary acidic protein (GFAP).</p> <p>Results</p> <p>By measuring the area density of immunoreactivity we found significantly more microglia and astrocytes in AD cases younger than 80 years compared to older AD patients. In addition, the presence of KP1, CR3/43 and GFAP decreases significantly with increasing age in AD.</p> <p>Conclusion</p> <p>Our data suggest that the association between neuroinflammation and AD is stronger in relatively young patients than in the oldest patients. This age-dependent relationship between inflammation and clinical phenotype of AD has implications for the interpretation of biomarkers and treatment of the disease.</p> http://www.jneuroinflammation.com/content/8/1/171Alzheimer's diseasemicrogliaastrocyteaging
collection DOAJ
language English
format Article
sources DOAJ
author Hoozemans Jeroen JM
Rozemuller Annemieke JM
van Haastert Elise S
Eikelenboom Piet
van Gool Willem A
spellingShingle Hoozemans Jeroen JM
Rozemuller Annemieke JM
van Haastert Elise S
Eikelenboom Piet
van Gool Willem A
Neuroinflammation in Alzheimer's disease wanes with age
Journal of Neuroinflammation
Alzheimer's disease
microglia
astrocyte
aging
author_facet Hoozemans Jeroen JM
Rozemuller Annemieke JM
van Haastert Elise S
Eikelenboom Piet
van Gool Willem A
author_sort Hoozemans Jeroen JM
title Neuroinflammation in Alzheimer's disease wanes with age
title_short Neuroinflammation in Alzheimer's disease wanes with age
title_full Neuroinflammation in Alzheimer's disease wanes with age
title_fullStr Neuroinflammation in Alzheimer's disease wanes with age
title_full_unstemmed Neuroinflammation in Alzheimer's disease wanes with age
title_sort neuroinflammation in alzheimer's disease wanes with age
publisher BMC
series Journal of Neuroinflammation
issn 1742-2094
publishDate 2011-12-01
description <p>Abstract</p> <p>Background</p> <p>Inflammation is a prominent feature in Alzheimer's disease (AD). It has been proposed that aging has an effect on the function of inflammation in the brain, thereby contributing to the development of age-related diseases like AD. However, the age-dependent relationship between inflammation and clinical phenotype of AD has never been investigated.</p> <p>Methods</p> <p>In this study we have analysed features of the neuroinflammatory response in clinically and pathologically confirmed AD and control cases in relation to age (range 52-97 years). The mid-temporal cortex of 19 controls and 19 AD cases was assessed for the occurrence of microglia and astrocytes by immunohistochemistry using antibodies directed against CD68 (KP1), HLA class II (CR3/43) and glial fibrillary acidic protein (GFAP).</p> <p>Results</p> <p>By measuring the area density of immunoreactivity we found significantly more microglia and astrocytes in AD cases younger than 80 years compared to older AD patients. In addition, the presence of KP1, CR3/43 and GFAP decreases significantly with increasing age in AD.</p> <p>Conclusion</p> <p>Our data suggest that the association between neuroinflammation and AD is stronger in relatively young patients than in the oldest patients. This age-dependent relationship between inflammation and clinical phenotype of AD has implications for the interpretation of biomarkers and treatment of the disease.</p>
topic Alzheimer's disease
microglia
astrocyte
aging
url http://www.jneuroinflammation.com/content/8/1/171
work_keys_str_mv AT hoozemansjeroenjm neuroinflammationinalzheimersdiseasewaneswithage
AT rozemullerannemiekejm neuroinflammationinalzheimersdiseasewaneswithage
AT vanhaastertelises neuroinflammationinalzheimersdiseasewaneswithage
AT eikelenboompiet neuroinflammationinalzheimersdiseasewaneswithage
AT vangoolwillema neuroinflammationinalzheimersdiseasewaneswithage
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