Targeting Autophagy in Breast Cancer
Breast cancer is a heterogeneous disease consisting of different biological subtypes, with differences in terms of incidence, response to diverse treatments, risk of disease progression, and sites of metastases. In the last years, several molecular targets have emerged and new drugs, targeting PI3K/...
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doaj-3e8da519a6904dde9f41f3b614c582c22020-11-25T03:35:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672020-10-01217836783610.3390/ijms21217836Targeting Autophagy in Breast CancerStefania Cocco0Alessandra Leone1Michela Piezzo2Roberta Caputo3Vincenzo Di Lauro4Francesca Di Rella5Giuseppina Fusco6Monica Capozzi7Germira di Gioia8Alfredo Budillon9Michelino De Laurentiis10Breast Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyExperimental Pharmacology Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyBreast Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyBreast Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyBreast Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyBreast Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyBreast Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyBreast Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyBreast Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyExperimental Pharmacology Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyBreast Unit, Istituto Nazionale Tumori IRCCS “Fondazione G. Pascale”, Via Mariano Semmola, 53, 80131 Napoli NA, ItalyBreast cancer is a heterogeneous disease consisting of different biological subtypes, with differences in terms of incidence, response to diverse treatments, risk of disease progression, and sites of metastases. In the last years, several molecular targets have emerged and new drugs, targeting PI3K/Akt/mTOR and cyclinD/CDK/pRb pathways and tumor microenvironment have been integrated into clinical practice. However, it is clear now that breast cancer is able to develop resistance to these drugs and the identification of the underlying molecular mechanisms is paramount to drive further drug development. Autophagy is a highly conserved homeostatic process that can be activated in response to antineoplastic agents as a cytoprotective mechanism. Inhibition of autophagy could enhance tumor cell death by diverse anti-cancer therapies, representing an attractive approach to control mechanisms of drug resistance. In this manuscript, we present a review of autophagy focusing on its interplay with targeted drugs used for breast cancer treatment.https://www.mdpi.com/1422-0067/21/21/7836breast cancerautophagyATGChloroquineHydroxychloroquineACD |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Stefania Cocco Alessandra Leone Michela Piezzo Roberta Caputo Vincenzo Di Lauro Francesca Di Rella Giuseppina Fusco Monica Capozzi Germira di Gioia Alfredo Budillon Michelino De Laurentiis |
spellingShingle |
Stefania Cocco Alessandra Leone Michela Piezzo Roberta Caputo Vincenzo Di Lauro Francesca Di Rella Giuseppina Fusco Monica Capozzi Germira di Gioia Alfredo Budillon Michelino De Laurentiis Targeting Autophagy in Breast Cancer International Journal of Molecular Sciences breast cancer autophagy ATG Chloroquine Hydroxychloroquine ACD |
author_facet |
Stefania Cocco Alessandra Leone Michela Piezzo Roberta Caputo Vincenzo Di Lauro Francesca Di Rella Giuseppina Fusco Monica Capozzi Germira di Gioia Alfredo Budillon Michelino De Laurentiis |
author_sort |
Stefania Cocco |
title |
Targeting Autophagy in Breast Cancer |
title_short |
Targeting Autophagy in Breast Cancer |
title_full |
Targeting Autophagy in Breast Cancer |
title_fullStr |
Targeting Autophagy in Breast Cancer |
title_full_unstemmed |
Targeting Autophagy in Breast Cancer |
title_sort |
targeting autophagy in breast cancer |
publisher |
MDPI AG |
series |
International Journal of Molecular Sciences |
issn |
1661-6596 1422-0067 |
publishDate |
2020-10-01 |
description |
Breast cancer is a heterogeneous disease consisting of different biological subtypes, with differences in terms of incidence, response to diverse treatments, risk of disease progression, and sites of metastases. In the last years, several molecular targets have emerged and new drugs, targeting PI3K/Akt/mTOR and cyclinD/CDK/pRb pathways and tumor microenvironment have been integrated into clinical practice. However, it is clear now that breast cancer is able to develop resistance to these drugs and the identification of the underlying molecular mechanisms is paramount to drive further drug development. Autophagy is a highly conserved homeostatic process that can be activated in response to antineoplastic agents as a cytoprotective mechanism. Inhibition of autophagy could enhance tumor cell death by diverse anti-cancer therapies, representing an attractive approach to control mechanisms of drug resistance. In this manuscript, we present a review of autophagy focusing on its interplay with targeted drugs used for breast cancer treatment. |
topic |
breast cancer autophagy ATG Chloroquine Hydroxychloroquine ACD |
url |
https://www.mdpi.com/1422-0067/21/21/7836 |
work_keys_str_mv |
AT stefaniacocco targetingautophagyinbreastcancer AT alessandraleone targetingautophagyinbreastcancer AT michelapiezzo targetingautophagyinbreastcancer AT robertacaputo targetingautophagyinbreastcancer AT vincenzodilauro targetingautophagyinbreastcancer AT francescadirella targetingautophagyinbreastcancer AT giuseppinafusco targetingautophagyinbreastcancer AT monicacapozzi targetingautophagyinbreastcancer AT germiradigioia targetingautophagyinbreastcancer AT alfredobudillon targetingautophagyinbreastcancer AT michelinodelaurentiis targetingautophagyinbreastcancer |
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1724554808382193664 |