Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary Syndrome
BackgroundGut microbiota dysbiosis can contribute to the progression of atherosclerosis. We investigated the association of the gut microbiota and the severity of coronary artery lesions and prognosis of patients with ACS.MethodsIn this case-control study, 402 ACS patients and 100 controls were enro...
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doaj-3e96b83df8f24135aaadab44426dd62a2021-09-07T05:35:35ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882021-09-011110.3389/fcimb.2021.687827687827Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary SyndromeJing Gao0Jing Gao1Jing Gao2Jie Wang3Li-Li Zhao4Ting-Ting Yao5Yang Chen6Jing Ma7Xu Zhang8Jing-Xian Wang9Yuan Wang10Zhuang Cui11Yin Liu12Yin Liu13Thoracic Clinical College, Tianjin Medical University, Tianjin, ChinaChest Hospital, Tianjin University, Tianjin, ChinaCardiovascular Institute, Tianjin Chest Hospital, Tianjin, ChinaSchool of Public Health, Tianjin Medical University, Tianjin, ChinaCardiovascular Institute, Tianjin Chest Hospital, Tianjin, ChinaSchool of Public Health, Tianjin Medical University, Tianjin, ChinaSchool of Public Health, Tianjin Medical University, Tianjin, ChinaCardiovascular Institute, Tianjin Chest Hospital, Tianjin, ChinaCardiovascular Institute, Tianjin Chest Hospital, Tianjin, ChinaThoracic Clinical College, Tianjin Medical University, Tianjin, ChinaThoracic Clinical College, Tianjin Medical University, Tianjin, ChinaSchool of Public Health, Tianjin Medical University, Tianjin, ChinaThoracic Clinical College, Tianjin Medical University, Tianjin, ChinaDepartment of Cardiology, Tianjin Chest Hospital, Tianjin, ChinaBackgroundGut microbiota dysbiosis can contribute to the progression of atherosclerosis. We investigated the association of the gut microbiota and the severity of coronary artery lesions and prognosis of patients with ACS.MethodsIn this case-control study, 402 ACS patients and 100 controls were enrolled from June 2017 to December 2018. The number of bacterial species was determined by real-time PCR. A SYNTAX score was calculated for all ACS patients based on their coronary angiography results.ResultsCompared with the healthy controls, the gut microbial levels in Escherichia coli, Streptococcus, and Enterobacteriaceae were significantly increased in ACS patients, while the Lactobacillus level was significantly decreased. Lactobacillus level was as an independent predictor of disease severity on the coronary angiography [high vs. low SYNTAX score: adjusted odds ratio (aOR) = 0.024, 95% confidence interval (CI): 0.004–0.155] and myocardial necrosis [high vs. low cardiac troponin T (cTNT): aOR = 0.317, 95% CI: 0.099–0.914]. Subsequently, a higher Lactobacillus level was associated with a lower risk of an all-cause death [adjusted hazard ratio (aHR) = 0.239; 95% CI: 0.093–0.617] and major adverse cardiac events (MACE) in ACS patients (aHR = 0.208; 95% CI: 0.081–0.531). After stratifying by the type of ACS, a higher Lactobacillus level was significantly associated with the decreased risks of high SYNTAX score, all-cause death, and MACE in the STEMI subgroup but not in the NSTEMI and UAP subgroups.ConclusionsLower Lactobacillus levels may indicate a higher risk of a more severe coronary atherosclerotic lesions and myocardial necrosis and worse prognosis for patients with ACS, particularly in the STEMI subgroup.https://www.frontiersin.org/articles/10.3389/fcimb.2021.687827/fullacute coronary syndromegut microbiotacoronary atherosclerotic lesionmyocardial necrosisprognosis |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Jing Gao Jing Gao Jing Gao Jie Wang Li-Li Zhao Ting-Ting Yao Yang Chen Jing Ma Xu Zhang Jing-Xian Wang Yuan Wang Zhuang Cui Yin Liu Yin Liu |
spellingShingle |
Jing Gao Jing Gao Jing Gao Jie Wang Li-Li Zhao Ting-Ting Yao Yang Chen Jing Ma Xu Zhang Jing-Xian Wang Yuan Wang Zhuang Cui Yin Liu Yin Liu Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary Syndrome Frontiers in Cellular and Infection Microbiology acute coronary syndrome gut microbiota coronary atherosclerotic lesion myocardial necrosis prognosis |
author_facet |
Jing Gao Jing Gao Jing Gao Jie Wang Li-Li Zhao Ting-Ting Yao Yang Chen Jing Ma Xu Zhang Jing-Xian Wang Yuan Wang Zhuang Cui Yin Liu Yin Liu |
author_sort |
Jing Gao |
title |
Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary Syndrome |
title_short |
Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary Syndrome |
title_full |
Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary Syndrome |
title_fullStr |
Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary Syndrome |
title_full_unstemmed |
Gut Lactobacillus Level Is a Predictive Marker for Coronary Atherosclerotic Lesions Progress and Prognosis in Patients With Acute Coronary Syndrome |
title_sort |
gut lactobacillus level is a predictive marker for coronary atherosclerotic lesions progress and prognosis in patients with acute coronary syndrome |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Cellular and Infection Microbiology |
issn |
2235-2988 |
publishDate |
2021-09-01 |
description |
BackgroundGut microbiota dysbiosis can contribute to the progression of atherosclerosis. We investigated the association of the gut microbiota and the severity of coronary artery lesions and prognosis of patients with ACS.MethodsIn this case-control study, 402 ACS patients and 100 controls were enrolled from June 2017 to December 2018. The number of bacterial species was determined by real-time PCR. A SYNTAX score was calculated for all ACS patients based on their coronary angiography results.ResultsCompared with the healthy controls, the gut microbial levels in Escherichia coli, Streptococcus, and Enterobacteriaceae were significantly increased in ACS patients, while the Lactobacillus level was significantly decreased. Lactobacillus level was as an independent predictor of disease severity on the coronary angiography [high vs. low SYNTAX score: adjusted odds ratio (aOR) = 0.024, 95% confidence interval (CI): 0.004–0.155] and myocardial necrosis [high vs. low cardiac troponin T (cTNT): aOR = 0.317, 95% CI: 0.099–0.914]. Subsequently, a higher Lactobacillus level was associated with a lower risk of an all-cause death [adjusted hazard ratio (aHR) = 0.239; 95% CI: 0.093–0.617] and major adverse cardiac events (MACE) in ACS patients (aHR = 0.208; 95% CI: 0.081–0.531). After stratifying by the type of ACS, a higher Lactobacillus level was significantly associated with the decreased risks of high SYNTAX score, all-cause death, and MACE in the STEMI subgroup but not in the NSTEMI and UAP subgroups.ConclusionsLower Lactobacillus levels may indicate a higher risk of a more severe coronary atherosclerotic lesions and myocardial necrosis and worse prognosis for patients with ACS, particularly in the STEMI subgroup. |
topic |
acute coronary syndrome gut microbiota coronary atherosclerotic lesion myocardial necrosis prognosis |
url |
https://www.frontiersin.org/articles/10.3389/fcimb.2021.687827/full |
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