No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty
Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) wit...
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doaj-3ea2db625b4f45249f65735c24e8fc832020-11-24T21:05:36ZengHindawi LimitedBioMed Research International2314-61332314-61412018-01-01201810.1155/2018/36874153687415No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip ArthroplastyTünay Aydin-Yüce0Gina Kurscheid1Hagen Sjard Bachmann2Thorsten Gehrke3Marcel Dudda4Markus Jäger5Christian Wedemeyer6Max Daniel Kauther7Department of Orthopaedics and Trauma Surgery, University Hospital Essen, Hufelandstraße 55, 45147 Essen, GermanyDepartment of Orthopaedics and Trauma Surgery, University Hospital Essen, Hufelandstraße 55, 45147 Essen, GermanyInstitute of Pharmacology and Toxicology, Witten/Herdecke University, Alfred-Herrhausen-Straße 50, 58455 Witten, GermanyDepartment of Joint Surgery, Helios ENDO-Klinik Hamburg, Holstenstraße 2, 22767 Hamburg, GermanyDepartment of Orthopaedics and Trauma Surgery, University Hospital Essen, Hufelandstraße 55, 45147 Essen, GermanyDepartment of Orthopaedics and Trauma Surgery, University Hospital Essen, Hufelandstraße 55, 45147 Essen, GermanyDepartment of Orthopaedics and Trauma Surgery, St. Barbara Hospital Gladbeck, Barbarastraße 1, 45964 Gladbeck, GermanyDepartment of Orthopaedics and Trauma Surgery, University Hospital Essen, Hufelandstraße 55, 45147 Essen, GermanyStudies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to aseptic loosening after THA. 320 patients suffering from aseptic loosening after primary total hip arthroplasty were genotyped for CALCA-P1 polymorphism and 161 patients for CALCA-P2 and CALCA-P3 polymorphisms and 160 patients for CALCA-P4 polymorphism. CALCA genotypes were determined by polymerase chain reaction and restriction-fragment length polymorphism. The genotype distribution of CALCA-P1 was CC 10%, CT 43%, and 46% TT. CALCA-P2 showed a distribution of 90.7%II, 8.7% ID, and 0.6% DD. The CALCA-P3 genotype distribution was 97.5% TT and 2.5% TC. The CALCA-P4 genotype distribution was 48.1% AA, 40% AT, and 11.9% TT. Significant differences between the CALCA genotypes were not found concerning age at implantation and replantation, BMI, gender, and cementation technique. No associations of the time for aseptic loosening were found. In conclusion, we did not find a significant association of CALCA polymorphisms and the time to aseptic loosening after primary THA in a Western European group.http://dx.doi.org/10.1155/2018/3687415 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Tünay Aydin-Yüce Gina Kurscheid Hagen Sjard Bachmann Thorsten Gehrke Marcel Dudda Markus Jäger Christian Wedemeyer Max Daniel Kauther |
spellingShingle |
Tünay Aydin-Yüce Gina Kurscheid Hagen Sjard Bachmann Thorsten Gehrke Marcel Dudda Markus Jäger Christian Wedemeyer Max Daniel Kauther No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty BioMed Research International |
author_facet |
Tünay Aydin-Yüce Gina Kurscheid Hagen Sjard Bachmann Thorsten Gehrke Marcel Dudda Markus Jäger Christian Wedemeyer Max Daniel Kauther |
author_sort |
Tünay Aydin-Yüce |
title |
No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty |
title_short |
No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty |
title_full |
No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty |
title_fullStr |
No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty |
title_full_unstemmed |
No Association of CALCA Polymorphisms and Aseptic Loosening after Primary Total Hip Arthroplasty |
title_sort |
no association of calca polymorphisms and aseptic loosening after primary total hip arthroplasty |
publisher |
Hindawi Limited |
series |
BioMed Research International |
issn |
2314-6133 2314-6141 |
publishDate |
2018-01-01 |
description |
Studies of aseptic loosening showed an influence of calcitonin and α-CGRP, both encoded from the calcitonin/α-CGRP (CALCA) gene by alternative splicing. The aim of this study was to detect a possible association of the CALCA polymorphisms P1(rs1553005), P2(rs35815751), P3(rs5240), and P4(rs2956) with the time to aseptic loosening after THA. 320 patients suffering from aseptic loosening after primary total hip arthroplasty were genotyped for CALCA-P1 polymorphism and 161 patients for CALCA-P2 and CALCA-P3 polymorphisms and 160 patients for CALCA-P4 polymorphism. CALCA genotypes were determined by polymerase chain reaction and restriction-fragment length polymorphism. The genotype distribution of CALCA-P1 was CC 10%, CT 43%, and 46% TT. CALCA-P2 showed a distribution of 90.7%II, 8.7% ID, and 0.6% DD. The CALCA-P3 genotype distribution was 97.5% TT and 2.5% TC. The CALCA-P4 genotype distribution was 48.1% AA, 40% AT, and 11.9% TT. Significant differences between the CALCA genotypes were not found concerning age at implantation and replantation, BMI, gender, and cementation technique. No associations of the time for aseptic loosening were found. In conclusion, we did not find a significant association of CALCA polymorphisms and the time to aseptic loosening after primary THA in a Western European group. |
url |
http://dx.doi.org/10.1155/2018/3687415 |
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