Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner

Nociceptin/orphanin FQ modulates energy homeostasis through inhibition of neurotransmission at VMN SF-1/ARC POMC synapses in a sex- and diet-dependent manner

Abstract Background Orphanin FQ (aka nociceptin; N/OFQ) binds to its nociceptin opioid peptide (NOP) receptor expressed in proopiomelanocortin (POMC) neurons within the arcuate nucleus (ARC), a critical anorexigenic component of the hypothalamic energy balance circuitry. It inhibits POMC neurons by...

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Bibliographic Details
Main Authors: Jennifer Hernandez, Carolina Fabelo, Lynnea Perez, Clare Moore, Rachel Chang, Edward J. Wagner
Format: Article
Language:English
Published: BMC 2019-02-01
Series:Biology of Sex Differences
Subjects:
Nociceptin/orphanin FQ
Proopiomelanocortin
Steroidogenic factor-1
Opioid receptor-like 1
Obesity
Insulin resistance
Online Access:http://link.springer.com/article/10.1186/s13293-019-0220-3

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