Protein context shapes the specificity of SH3 domain-mediated interactions in vivo
The SRC Homology 3 (SH3) domains mediate protein–protein interactions (PPIs). Here, the authors assess the SH3-mediated PPIs in yeast, and show that the identity of the protein itself and the position of the SH3 both affect the interaction specificity and thus the PPI-dependent cellular functions.
Bibliographic Details
Main Authors: |
Ugo Dionne,
Émilie Bourgault,
Alexandre K. Dubé,
David Bradley,
François J. M. Chartier,
Rohan Dandage,
Soham Dibyachintan,
Philippe C. Després,
Gerald D. Gish,
N. T. Hang Pham,
Myriam Létourneau,
Jean-Philippe Lambert,
Nicolas Doucet,
Nicolas Bisson,
Christian R. Landry |
Format: | Article
|
Language: | English |
Published: |
Nature Publishing Group
2021-03-01
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Series: | Nature Communications
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Online Access: | https://doi.org/10.1038/s41467-021-21873-2
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