Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Direct visualization of microglia-mediated synapse pruning has been lacking. This study shows direct evidence of microglia-synapse interaction where microglia do not necessarily ‘eat’ post-synaptic structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.

Bibliographic Details
Main Authors: Laetitia Weinhard, Giulia di Bartolomei, Giulia Bolasco, Pedro Machado, Nicole L. Schieber, Urte Neniskyte, Melanie Exiga, Auguste Vadisiute, Angelo Raggioli, Andreas Schertel, Yannick Schwab, Cornelius T. Gross
Format: Article
Language:English
Published: Nature Publishing Group 2018-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-03566-5
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spelling doaj-3ebaa88953d7458785bcccb29c6b1bc72021-05-11T09:29:27ZengNature Publishing GroupNature Communications2041-17232018-03-019111410.1038/s41467-018-03566-5Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia inductionLaetitia Weinhard0Giulia di Bartolomei1Giulia Bolasco2Pedro Machado3Nicole L. Schieber4Urte Neniskyte5Melanie Exiga6Auguste Vadisiute7Angelo Raggioli8Andreas Schertel9Yannick Schwab10Cornelius T. Gross11Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory (EMBL)Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory (EMBL)Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory (EMBL)Electron Microscopy Core Facility, European Molecular Biology Laboratory (EMBL)Cell Biology and Biophysics Unit, European Molecular Biology Laboratory (EMBL)Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory (EMBL)Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory (EMBL)Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory (EMBL)Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory (EMBL)Carl Zeiss Microscopy GmbH, ZEISS GroupElectron Microscopy Core Facility, European Molecular Biology Laboratory (EMBL)Epigenetics and Neurobiology Unit, European Molecular Biology Laboratory (EMBL)Direct visualization of microglia-mediated synapse pruning has been lacking. This study shows direct evidence of microglia-synapse interaction where microglia do not necessarily ‘eat’ post-synaptic structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.https://doi.org/10.1038/s41467-018-03566-5
collection DOAJ
language English
format Article
sources DOAJ
author Laetitia Weinhard
Giulia di Bartolomei
Giulia Bolasco
Pedro Machado
Nicole L. Schieber
Urte Neniskyte
Melanie Exiga
Auguste Vadisiute
Angelo Raggioli
Andreas Schertel
Yannick Schwab
Cornelius T. Gross
spellingShingle Laetitia Weinhard
Giulia di Bartolomei
Giulia Bolasco
Pedro Machado
Nicole L. Schieber
Urte Neniskyte
Melanie Exiga
Auguste Vadisiute
Angelo Raggioli
Andreas Schertel
Yannick Schwab
Cornelius T. Gross
Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
Nature Communications
author_facet Laetitia Weinhard
Giulia di Bartolomei
Giulia Bolasco
Pedro Machado
Nicole L. Schieber
Urte Neniskyte
Melanie Exiga
Auguste Vadisiute
Angelo Raggioli
Andreas Schertel
Yannick Schwab
Cornelius T. Gross
author_sort Laetitia Weinhard
title Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_short Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_full Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_fullStr Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_full_unstemmed Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
title_sort microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2018-03-01
description Direct visualization of microglia-mediated synapse pruning has been lacking. This study shows direct evidence of microglia-synapse interaction where microglia do not necessarily ‘eat’ post-synaptic structure but ‘nibble’ on pre-synaptic terminals, much akin to trogocytosis by lymphocytes.
url https://doi.org/10.1038/s41467-018-03566-5
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