Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]

Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]

B lymphocytes promote the initial innate interferon response to viral pathogens without the need for antigen receptor activation. B cell dependent IFN production requires the cytokine, lymphotoxin-β. The LTβ pathway is well known to regulate lymphoid organogenesis and homeostasis by differentiating...

Full description

Bibliographic Details
Main Authors: Carl F Ware, Chris Benedict
Format: Article
Language:English
Published: F1000 Research Ltd 2012-08-01
Series:F1000Research
Subjects:
Immunity to Infections
Innate Immunity
Leukocyte Activation
Online Access:http://f1000research.com/articles/1-8/v1
id doaj-3ebdf9e864774df3a383d64ebd6a93b9
record_format Article
spelling doaj-3ebdf9e864774df3a383d64ebd6a93b92020-11-25T03:25:21ZengF1000 Research LtdF1000Research2046-14022012-08-01110.12688/f1000research.1-8.v1104Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]Carl F Ware0Chris Benedict1Laboratory of Molecular Immunology, Infectious and Inflammatory Diseases Center, Sanford-Burnham Medical Research Institute, California, 92037, USADivision of Immune Regulation, La Jolla Institute for Allergy and Immunology, California, 92037, USAB lymphocytes promote the initial innate interferon response to viral pathogens without the need for antigen receptor activation. B cell dependent IFN production requires the cytokine, lymphotoxin-β. The LTβ pathway is well known to regulate lymphoid organogenesis and homeostasis by differentiating stromal cells and macrophages. However, in response to viral pathogens these same B cell-regulated populations rapidly produce type 1 interferons. Thus, B cells act as innate effector cells via LTβ homeostatic pathways, which serve as innate host barriers to viral pathogens.http://f1000research.com/articles/1-8/v1Immunity to InfectionsInnate ImmunityLeukocyte Activation
collection DOAJ
language English
format Article
sources DOAJ
author Carl F Ware
Chris Benedict
spellingShingle Carl F Ware
Chris Benedict
Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]
F1000Research
Immunity to Infections
Innate Immunity
Leukocyte Activation
author_facet Carl F Ware
Chris Benedict
author_sort Carl F Ware
title Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]
title_short Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]
title_full Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]
title_fullStr Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]
title_full_unstemmed Innate B cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/T4CAVP]
title_sort innate b cells: oxymoron or validated concept? [v1; ref status: indexed, http://f1000r.es/t4cavp]
publisher F1000 Research Ltd
series F1000Research
issn 2046-1402
publishDate 2012-08-01
description B lymphocytes promote the initial innate interferon response to viral pathogens without the need for antigen receptor activation. B cell dependent IFN production requires the cytokine, lymphotoxin-β. The LTβ pathway is well known to regulate lymphoid organogenesis and homeostasis by differentiating stromal cells and macrophages. However, in response to viral pathogens these same B cell-regulated populations rapidly produce type 1 interferons. Thus, B cells act as innate effector cells via LTβ homeostatic pathways, which serve as innate host barriers to viral pathogens.
topic Immunity to Infections
Innate Immunity
Leukocyte Activation
url http://f1000research.com/articles/1-8/v1
work_keys_str_mv AT carlfware innatebcellsoxymoronorvalidatedconceptv1refstatusindexedhttpf1000rest4cavp
AT chrisbenedict innatebcellsoxymoronorvalidatedconceptv1refstatusindexedhttpf1000rest4cavp
_version_ 1724597396271267840

Similar Items