A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome

A hepatitis B virus transgenic mouse model with a conditional, recombinant, episomal genome

Background & Aims: Development of new and more effective therapies against hepatitis B virus (HBV) is limited by the lack of suitable small animal models. The HBV transgenic mouse model containing an integrated overlength 1.3-mer construct has yielded crucial insights, but this model unfortu...

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Bibliographic Details
Main Authors: Robert L. Kruse, Mercedes Barzi, Xavier Legras, Francis P. Pankowicz, Nika Furey, Lan Liao, Janming Xu, Beatrice Bissig-Choisat, Betty L. Slagle, Karl-Dimiter Bissig
Format: Article
Language:English
Published: Elsevier 2021-04-01
Series:JHEP Reports
Subjects:
Hepatitis B virus
Transgenic mouse
Cre/LoxP
cccDNA
Online Access:http://www.sciencedirect.com/science/article/pii/S2589555921000288

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http://www.sciencedirect.com/science/article/pii/S2589555921000288

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