Beneficial effects of crude extract of Eupatorium lindleyanum DC. in hyperlipidemia and atherosclerosis
The aim of this study was to evaluate the effects of crude extract of Eupatorium lindleyanum DC. (CEEL) on reducing hyperlipidemia and preventing atherosclerosis induced with a high cholesterol diet (HCD) in rabbits. The levels of total cholesterol, triglyceride and low-density lipoprotein cholester...
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2016-01-01
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Online Access: | http://dx.doi.org/10.1080/13102818.2015.1088796 |
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doaj-3ef935d31f2446be8fd23c87d615e8382020-11-25T02:02:19ZengTaylor & Francis GroupBiotechnology & Biotechnological Equipment1310-28181314-35302016-01-0130115115710.1080/13102818.2015.10887961088796Beneficial effects of crude extract of Eupatorium lindleyanum DC. in hyperlipidemia and atherosclerosisXing Zhou0Guohong Song1Xiaomei Zhang2Xuming Liang3Qing Li4Jie Zhang5Yuanda Zhou6Chongqing Academy of Chinese Materia MedicaChongqing Academy of Chinese Materia MedicaChongqing Academy of Chinese Materia MedicaChongqing Academy of Chinese Materia MedicaChongqing Academy of Chinese Materia MedicaChongqing Technology and Business UniversityChongqing Medical UniversityThe aim of this study was to evaluate the effects of crude extract of Eupatorium lindleyanum DC. (CEEL) on reducing hyperlipidemia and preventing atherosclerosis induced with a high cholesterol diet (HCD) in rabbits. The levels of total cholesterol, triglyceride and low-density lipoprotein cholesterol were lower in the serum of rabbits fed HCD plus CEEL or simvastatin than in the serum of rabbits fed HCD. Rabbits in the CEEL and simvastatin groups showed a significant decrease in the expression of C-reactive protein, an increase in the level of NO and low level expression of vascular cell adhesion molecule-1 compared with the model group (fed with HCD). Feeding CEEL to rabbits significantly reduced severe atherosclerosis in the aorta. Histopathological examination showed that CEEL reduced foam cell formation and inhibited smooth muscle cell migration in the blood vessel of rabbits. These effects may account for beneficial effects of CEEL in hyperlipidemia and atherosclerosis.http://dx.doi.org/10.1080/13102818.2015.1088796Eupatorium lindleyanum DCextracthyperlipidemiaatherosclerosisserum lipid |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Xing Zhou Guohong Song Xiaomei Zhang Xuming Liang Qing Li Jie Zhang Yuanda Zhou |
spellingShingle |
Xing Zhou Guohong Song Xiaomei Zhang Xuming Liang Qing Li Jie Zhang Yuanda Zhou Beneficial effects of crude extract of Eupatorium lindleyanum DC. in hyperlipidemia and atherosclerosis Biotechnology & Biotechnological Equipment Eupatorium lindleyanum DC extract hyperlipidemia atherosclerosis serum lipid |
author_facet |
Xing Zhou Guohong Song Xiaomei Zhang Xuming Liang Qing Li Jie Zhang Yuanda Zhou |
author_sort |
Xing Zhou |
title |
Beneficial effects of crude extract of Eupatorium lindleyanum DC. in hyperlipidemia and atherosclerosis |
title_short |
Beneficial effects of crude extract of Eupatorium lindleyanum DC. in hyperlipidemia and atherosclerosis |
title_full |
Beneficial effects of crude extract of Eupatorium lindleyanum DC. in hyperlipidemia and atherosclerosis |
title_fullStr |
Beneficial effects of crude extract of Eupatorium lindleyanum DC. in hyperlipidemia and atherosclerosis |
title_full_unstemmed |
Beneficial effects of crude extract of Eupatorium lindleyanum DC. in hyperlipidemia and atherosclerosis |
title_sort |
beneficial effects of crude extract of eupatorium lindleyanum dc. in hyperlipidemia and atherosclerosis |
publisher |
Taylor & Francis Group |
series |
Biotechnology & Biotechnological Equipment |
issn |
1310-2818 1314-3530 |
publishDate |
2016-01-01 |
description |
The aim of this study was to evaluate the effects of crude extract of Eupatorium lindleyanum DC. (CEEL) on reducing hyperlipidemia and preventing atherosclerosis induced with a high cholesterol diet (HCD) in rabbits. The levels of total cholesterol, triglyceride and low-density lipoprotein cholesterol were lower in the serum of rabbits fed HCD plus CEEL or simvastatin than in the serum of rabbits fed HCD. Rabbits in the CEEL and simvastatin groups showed a significant decrease in the expression of C-reactive protein, an increase in the level of NO and low level expression of vascular cell adhesion molecule-1 compared with the model group (fed with HCD). Feeding CEEL to rabbits significantly reduced severe atherosclerosis in the aorta. Histopathological examination showed that CEEL reduced foam cell formation and inhibited smooth muscle cell migration in the blood vessel of rabbits. These effects may account for beneficial effects of CEEL in hyperlipidemia and atherosclerosis. |
topic |
Eupatorium lindleyanum DC extract hyperlipidemia atherosclerosis serum lipid |
url |
http://dx.doi.org/10.1080/13102818.2015.1088796 |
work_keys_str_mv |
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