Design and Fabrication of Sodium Alginate/Carboxymethyl Cellulose Sodium Blend Hydrogel for Artificial Skin
Tissue-engineered skin grafts have long been considered to be the most effective treatment for large skin defects. Especially with the advent of 3D printing technology, the manufacture of artificial skin scaffold with complex shape and structure is becoming more convenient. However, the matrix mater...
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doaj-3efcc2767c864fd4ae92fac27e1eb4b22021-09-26T00:12:19ZengMDPI AGGels2310-28612021-08-01711511510.3390/gels7030115Design and Fabrication of Sodium Alginate/Carboxymethyl Cellulose Sodium Blend Hydrogel for Artificial SkinKun Zhang0Yanen Wang1Qinghua Wei2Xinpei Li3Ying Guo4Shan Zhang5Industry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaIndustry Engineering Department, School of Mechanical Engineering, Northwestern Polytechnical University, Xi’an 710072, ChinaTissue-engineered skin grafts have long been considered to be the most effective treatment for large skin defects. Especially with the advent of 3D printing technology, the manufacture of artificial skin scaffold with complex shape and structure is becoming more convenient. However, the matrix material used as the bio-ink for 3D printing artificial skin is still a challenge. To address this issue, sodium alginate (SA)/carboxymethyl cellulose (CMC-Na) blend hydrogel was proposed to be the bio-ink for artificial skin fabrication, and SA/CMC-Na (SC) composite hydrogels at different compositions were investigated in terms of morphology, thermal properties, mechanical properties, and biological properties, so as to screen out the optimal composition ratio of SC for 3D printing artificial skin. Moreover, the designed SC composite hydrogel skin membranes were used for rabbit wound defeat repairing to evaluate the repair effect. Results show that SC4:1 blend hydrogel possesses the best mechanical properties, good moisturizing ability, proper degradation rate, and good biocompatibility, which is most suitable for 3D printing artificial skin. This research provides a process guidance for the design and fabrication of SA/CMC-Na composite artificial skin.https://www.mdpi.com/2310-2861/7/3/115SA/CMC-Nahydrogel membraneartificial skin3D printingskin regenerationwound healing |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kun Zhang Yanen Wang Qinghua Wei Xinpei Li Ying Guo Shan Zhang |
spellingShingle |
Kun Zhang Yanen Wang Qinghua Wei Xinpei Li Ying Guo Shan Zhang Design and Fabrication of Sodium Alginate/Carboxymethyl Cellulose Sodium Blend Hydrogel for Artificial Skin Gels SA/CMC-Na hydrogel membrane artificial skin 3D printing skin regeneration wound healing |
author_facet |
Kun Zhang Yanen Wang Qinghua Wei Xinpei Li Ying Guo Shan Zhang |
author_sort |
Kun Zhang |
title |
Design and Fabrication of Sodium Alginate/Carboxymethyl Cellulose Sodium Blend Hydrogel for Artificial Skin |
title_short |
Design and Fabrication of Sodium Alginate/Carboxymethyl Cellulose Sodium Blend Hydrogel for Artificial Skin |
title_full |
Design and Fabrication of Sodium Alginate/Carboxymethyl Cellulose Sodium Blend Hydrogel for Artificial Skin |
title_fullStr |
Design and Fabrication of Sodium Alginate/Carboxymethyl Cellulose Sodium Blend Hydrogel for Artificial Skin |
title_full_unstemmed |
Design and Fabrication of Sodium Alginate/Carboxymethyl Cellulose Sodium Blend Hydrogel for Artificial Skin |
title_sort |
design and fabrication of sodium alginate/carboxymethyl cellulose sodium blend hydrogel for artificial skin |
publisher |
MDPI AG |
series |
Gels |
issn |
2310-2861 |
publishDate |
2021-08-01 |
description |
Tissue-engineered skin grafts have long been considered to be the most effective treatment for large skin defects. Especially with the advent of 3D printing technology, the manufacture of artificial skin scaffold with complex shape and structure is becoming more convenient. However, the matrix material used as the bio-ink for 3D printing artificial skin is still a challenge. To address this issue, sodium alginate (SA)/carboxymethyl cellulose (CMC-Na) blend hydrogel was proposed to be the bio-ink for artificial skin fabrication, and SA/CMC-Na (SC) composite hydrogels at different compositions were investigated in terms of morphology, thermal properties, mechanical properties, and biological properties, so as to screen out the optimal composition ratio of SC for 3D printing artificial skin. Moreover, the designed SC composite hydrogel skin membranes were used for rabbit wound defeat repairing to evaluate the repair effect. Results show that SC4:1 blend hydrogel possesses the best mechanical properties, good moisturizing ability, proper degradation rate, and good biocompatibility, which is most suitable for 3D printing artificial skin. This research provides a process guidance for the design and fabrication of SA/CMC-Na composite artificial skin. |
topic |
SA/CMC-Na hydrogel membrane artificial skin 3D printing skin regeneration wound healing |
url |
https://www.mdpi.com/2310-2861/7/3/115 |
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