| Summary: | The effects of the ethanol and dichloromethane extracts from the pericarp of <i>Garcinia mangostana</i> Linn.(<i>G. mangostana</i>) on nociceptive response using writhing and hot plate tests in mice and the antipyretic activity in yeastinduced fever in rats, were examined. Anti-inflammatory activity using carrageenin-induced paw edema in rats was also investigated. The ethanol extract (400, 800 mg/kg, p.o.) significantly suppressed the writhings induced by acetic acid. The dichloromethane extract (200, 400 and 800 mg/kg, p.o.) also decreased acetic acid-induced writhing in mice. Neither theethanol extract nor dichloromethane extract had significant effects on antinociceptive response in the hot plate test. No significanteffects on yeast-induced fever were observed after oral administration of the ethanol and dichloromethane extractsin rats. Either oral administration (800 mg/kg) of the ethanol extract or dichloromethane extract significantly decreased therat paw edema induced by carrageenin. These results suggest that the ethanol and dichloromethane extracts from the fruithull of <i>G. mangostana</i> possess analgesic and anti-inflammatory actions but no antipyretic action and one mechanism of action of the anti-inflammatory activity of the extracts may involve in cyclooxygenase (COX) inhibition.
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