A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

Li et al. analyzed structural connectivity of deep brain stimulation electrodes in 50 patients suffering from obsessive-compulsive disorder operated at four centers. Connectivity to a specific tract within the anterior limb of the internal capsule was associated with optimal treatment response acros...

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Main Authors:	Ningfei Li, Juan Carlos Baldermann, Astrid Kibleur, Svenja Treu, Harith Akram, Gavin J. B. Elias, Alexandre Boutet, Andres M. Lozano, Bassam Al-Fatly, Bryan Strange, Juan A. Barcia, Ludvic Zrinzo, Eileen Joyce, Stephan Chabardes, Veerle Visser-Vandewalle, Mircea Polosan, Jens Kuhn, Andrea A. Kühn, Andreas Horn
Format:	Article
Language:	English
Published:	Nature Publishing Group 2020-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-020-16734-3

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spelling	doaj-3f03043ad0d44175a12a3f056b070b932021-07-04T11:47:22ZengNature Publishing GroupNature Communications2041-17232020-07-0111111210.1038/s41467-020-16734-3A unified connectomic target for deep brain stimulation in obsessive-compulsive disorderNingfei Li0Juan Carlos Baldermann1Astrid Kibleur2Svenja Treu3Harith Akram4Gavin J. B. Elias5Alexandre Boutet6Andres M. Lozano7Bassam Al-Fatly8Bryan Strange9Juan A. Barcia10Ludvic Zrinzo11Eileen Joyce12Stephan Chabardes13Veerle Visser-Vandewalle14Mircea Polosan15Jens Kuhn16Andrea A. Kühn17Andreas Horn18Charité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for NeurologyDepartment of Psychiatry and Psychotherapy, Department of Neurology, University of Cologne, Medical FacultyUniv. Grenoble AlpesLaboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politecnica de MadridDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of NeurologyUniversity Health NetworkUniversity Health NetworkUniversity Health NetworkCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for NeurologyLaboratory for Clinical Neuroscience, Centre for Biomedical Technology, Universidad Politecnica de MadridHospital Clínico San Carlos, Neurosurgery Department, Universidad Complutense de MadridDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of NeurologyDepartment of Clinical and Movement Neurosciences, UCL Queen Square Institute of NeurologyUniv. Grenoble AlpesDepartment of Stereotactic and Functional Neurosurgery, University of CologneUniv. Grenoble AlpesDepartment of Psychiatry and Psychotherapy, Department of Neurology, University of Cologne, Medical FacultyCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for NeurologyCharité – Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Movement Disorders and Neuromodulation Unit, Department for NeurologyLi et al. analyzed structural connectivity of deep brain stimulation electrodes in 50 patients suffering from obsessive-compulsive disorder operated at four centers. Connectivity to a specific tract within the anterior limb of the internal capsule was associated with optimal treatment response across cohorts, surgeons and centers.https://doi.org/10.1038/s41467-020-16734-3
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Ningfei Li Juan Carlos Baldermann Astrid Kibleur Svenja Treu Harith Akram Gavin J. B. Elias Alexandre Boutet Andres M. Lozano Bassam Al-Fatly Bryan Strange Juan A. Barcia Ludvic Zrinzo Eileen Joyce Stephan Chabardes Veerle Visser-Vandewalle Mircea Polosan Jens Kuhn Andrea A. Kühn Andreas Horn
spellingShingle	Ningfei Li Juan Carlos Baldermann Astrid Kibleur Svenja Treu Harith Akram Gavin J. B. Elias Alexandre Boutet Andres M. Lozano Bassam Al-Fatly Bryan Strange Juan A. Barcia Ludvic Zrinzo Eileen Joyce Stephan Chabardes Veerle Visser-Vandewalle Mircea Polosan Jens Kuhn Andrea A. Kühn Andreas Horn A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder Nature Communications
author_facet	Ningfei Li Juan Carlos Baldermann Astrid Kibleur Svenja Treu Harith Akram Gavin J. B. Elias Alexandre Boutet Andres M. Lozano Bassam Al-Fatly Bryan Strange Juan A. Barcia Ludvic Zrinzo Eileen Joyce Stephan Chabardes Veerle Visser-Vandewalle Mircea Polosan Jens Kuhn Andrea A. Kühn Andreas Horn
author_sort	Ningfei Li
title	A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
title_short	A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
title_full	A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
title_fullStr	A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
title_full_unstemmed	A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
title_sort	unified connectomic target for deep brain stimulation in obsessive-compulsive disorder
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2020-07-01
description	Li et al. analyzed structural connectivity of deep brain stimulation electrodes in 50 patients suffering from obsessive-compulsive disorder operated at four centers. Connectivity to a specific tract within the anterior limb of the internal capsule was associated with optimal treatment response across cohorts, surgeons and centers.
url	https://doi.org/10.1038/s41467-020-16734-3
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A unified connectomic target for deep brain stimulation in obsessive-compulsive disorder

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