Chaperonology: The Third Eye on Brain Gliomas
The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to bala...
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doaj-3f036f9951934a9fa5d32ac550e3135e2020-11-24T21:09:55ZengMDPI AGBrain Sciences2076-34252018-06-018611010.3390/brainsci8060110brainsci8060110Chaperonology: The Third Eye on Brain GliomasFrancesca Graziano0C. Caruso Bavisotto1A. Marino Gammazza2Francesca Rappa3Everly Conway de Macario4Albert J. L. Macario5Francesco Cappello6Claudia Campanella7Rosario Maugeri8Domenico Gerardo Iacopino9Department of Experimental Biomedicine and Clinical Neuroscience, Section of Neurosurgery, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Microbiology and Immunology, School of Medicine, University of Maryland at Baltimore-Institute of Marine and Environmental Technology (IMET), Baltimore, MD 21202, USAEuro-Mediterranean Institute of Science and Technology (IEMEST), 90136 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Human Anatomy, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Neurosurgery, University of Palermo, 90127 Palermo, ItalyDepartment of Experimental Biomedicine and Clinical Neuroscience, Section of Neurosurgery, University of Palermo, 90127 Palermo, ItalyThe European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient’s neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents.http://www.mdpi.com/2076-3425/8/6/110high-grade gliomasmolecular chaperonesheat shock proteinsneuroimagingneuromonitoringchaperonologychaperonotherapy |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Francesca Graziano C. Caruso Bavisotto A. Marino Gammazza Francesca Rappa Everly Conway de Macario Albert J. L. Macario Francesco Cappello Claudia Campanella Rosario Maugeri Domenico Gerardo Iacopino |
spellingShingle |
Francesca Graziano C. Caruso Bavisotto A. Marino Gammazza Francesca Rappa Everly Conway de Macario Albert J. L. Macario Francesco Cappello Claudia Campanella Rosario Maugeri Domenico Gerardo Iacopino Chaperonology: The Third Eye on Brain Gliomas Brain Sciences high-grade gliomas molecular chaperones heat shock proteins neuroimaging neuromonitoring chaperonology chaperonotherapy |
author_facet |
Francesca Graziano C. Caruso Bavisotto A. Marino Gammazza Francesca Rappa Everly Conway de Macario Albert J. L. Macario Francesco Cappello Claudia Campanella Rosario Maugeri Domenico Gerardo Iacopino |
author_sort |
Francesca Graziano |
title |
Chaperonology: The Third Eye on Brain Gliomas |
title_short |
Chaperonology: The Third Eye on Brain Gliomas |
title_full |
Chaperonology: The Third Eye on Brain Gliomas |
title_fullStr |
Chaperonology: The Third Eye on Brain Gliomas |
title_full_unstemmed |
Chaperonology: The Third Eye on Brain Gliomas |
title_sort |
chaperonology: the third eye on brain gliomas |
publisher |
MDPI AG |
series |
Brain Sciences |
issn |
2076-3425 |
publishDate |
2018-06-01 |
description |
The European Organization for Research and Treatment of Cancer/National Cancer Institute of Canada Phase III trial has validated as a current regimen for high-grade gliomas (HGG) a maximal safe surgical resection followed by radiotherapy with concurrent temozolamide. However, it is essential to balance maximal tumor resection with preservation of the patient’s neurological functions. Important developments in the fields of pre-operative and intra-operative neuro-imaging and neuro-monitoring have ameliorated the survival rate and the quality of life for patients affected by HGG. Moreover, even though the natural history remains extremely poor, advancement in the molecular and genetic fields have opened up new potential frontiers in the management of this devastating brain disease. In this review, we aim to present a comprehensive account of the main current pre-operative, intra-operative and molecular approaches to HGG with particular attention to specific chaperones, also called heat shock proteins (Hsps), which represent potential novel biomarkers to detect and follow up HGG, and could also be therapeutic agents. |
topic |
high-grade gliomas molecular chaperones heat shock proteins neuroimaging neuromonitoring chaperonology chaperonotherapy |
url |
http://www.mdpi.com/2076-3425/8/6/110 |
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