A Chinese Family With Adult-Onset Leigh-Like Syndrome Caused by the Heteroplasmic m.10191T>C Mutation in the Mitochondrial MTND3 Gene

A Chinese Family With Adult-Onset Leigh-Like Syndrome Caused by the Heteroplasmic m.10191T>C Mutation in the Mitochondrial MTND3 Gene

Leigh syndrome (LS) is a mitochondrial disease of infancy and early childhood, that is rarely seen in adults. The high degree of genetic and clinical heterogeneity makes LS a very complex syndrome. The clinical manifestations include neurological symptoms and various non-neurological symptoms, with...

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Bibliographic Details
Main Authors: Tao-Ran Li, Qun Wang, Mao-Mao Liu, Rui-Juan Lv
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-04-01
Series:Frontiers in Neurology
Subjects:
Leigh syndrome
Leigh-like syndrome
MELAS
MELAS-LS overlap syndrome
m.10191T>C mutation
Online Access:https://www.frontiersin.org/article/10.3389/fneur.2019.00347/full

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