Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties

Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory Properties

Acid-sensing ion channels (ASICs), which are present in almost all types of neurons, play an important role in physiological and pathological processes. The ASIC1a subtype is the most sensitive channel to the medium’s acidification, and it plays an important role in the excitation of neuro...

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Bibliographic Details
Main Authors: Dmitry I. Osmakov, Sergey G. Koshelev, Victor A. Palikov, Yulia A. Palikova, Elvira R. Shaykhutdinova, Igor A. Dyachenko, Yaroslav A. Andreev, Sergey A. Kozlov
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Toxins
Subjects:
acid-sensing ion channel subtype 1a
bisbenzylisoquinoline alkaloid
lindoldhamine
nociception
inflammation
Online Access:https://www.mdpi.com/2072-6651/11/9/542

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https://www.mdpi.com/2072-6651/11/9/542

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