Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study
Background: Self-disturbances in schizophrenia have recently been explained by an abnormality in the sense of agency (SoA). The cerebral structures of SoA in healthy people are considered to mainly include the insula and inferior parietal lobule. In contrast, the functional lesion of aberrant SoA in...
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Frontiers Media S.A.
2019-04-01
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Online Access: | https://www.frontiersin.org/article/10.3389/fpsyt.2019.00171/full |
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DOAJ |
language |
English |
format |
Article |
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DOAJ |
author |
Akihiro Koreki Akihiro Koreki Akihiro Koreki Takaki Maeda Takaki Maeda Tsukasa Okimura Tsukasa Okimura Yuri Terasawa Yuri Terasawa Toshiaki Kikuchi Satoshi Umeda Satoshi Umeda Shiro Nishikata Shiro Nishikata Tatsuhiko Yagihashi Tatsuhiko Yagihashi Mari Kasahara Mari Kasahara Chiyoko Nagai Chiyoko Nagai Yasushi Moriyama Yasushi Moriyama Ryosuke Den Ryosuke Den Tamotsu Watanabe Tamotsu Watanabe Hirotsugu Kikumoto Motoichiro Kato Motoichiro Kato Masaru Mimura |
spellingShingle |
Akihiro Koreki Akihiro Koreki Akihiro Koreki Takaki Maeda Takaki Maeda Tsukasa Okimura Tsukasa Okimura Yuri Terasawa Yuri Terasawa Toshiaki Kikuchi Satoshi Umeda Satoshi Umeda Shiro Nishikata Shiro Nishikata Tatsuhiko Yagihashi Tatsuhiko Yagihashi Mari Kasahara Mari Kasahara Chiyoko Nagai Chiyoko Nagai Yasushi Moriyama Yasushi Moriyama Ryosuke Den Ryosuke Den Tamotsu Watanabe Tamotsu Watanabe Hirotsugu Kikumoto Motoichiro Kato Motoichiro Kato Masaru Mimura Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study Frontiers in Psychiatry schizophrenia sense of agency self-disturbance functional connectivity imaging caudate |
author_facet |
Akihiro Koreki Akihiro Koreki Akihiro Koreki Takaki Maeda Takaki Maeda Tsukasa Okimura Tsukasa Okimura Yuri Terasawa Yuri Terasawa Toshiaki Kikuchi Satoshi Umeda Satoshi Umeda Shiro Nishikata Shiro Nishikata Tatsuhiko Yagihashi Tatsuhiko Yagihashi Mari Kasahara Mari Kasahara Chiyoko Nagai Chiyoko Nagai Yasushi Moriyama Yasushi Moriyama Ryosuke Den Ryosuke Den Tamotsu Watanabe Tamotsu Watanabe Hirotsugu Kikumoto Motoichiro Kato Motoichiro Kato Masaru Mimura |
author_sort |
Akihiro Koreki |
title |
Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study |
title_short |
Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study |
title_full |
Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study |
title_fullStr |
Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study |
title_full_unstemmed |
Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging Study |
title_sort |
dysconnectivity of the agency network in schizophrenia: a functional magnetic resonance imaging study |
publisher |
Frontiers Media S.A. |
series |
Frontiers in Psychiatry |
issn |
1664-0640 |
publishDate |
2019-04-01 |
description |
Background: Self-disturbances in schizophrenia have recently been explained by an abnormality in the sense of agency (SoA). The cerebral structures of SoA in healthy people are considered to mainly include the insula and inferior parietal lobule. In contrast, the functional lesion of aberrant SoA in schizophrenia is not yet fully understood. Considering the recent explanation of establishing SoA from the standpoint of associative learning, the “agency network” may include not only the insula and inferior parietal lobule but also the striatum. We hypothesized that aberrant SoA in schizophrenia is based on a deficit in the “agency network.”Methods: Functional magnetic resonance imaging data were acquired while patients with schizophrenia (n = 15) and matched controls (n = 15) performed our adaptation method of agency attribution task on a trial-by-trial basis to assess participants' explicit experience of the temporal causal relationship between an action and an external event with temporal biases. Analysis of functional connectivity was done using the right supramarginal gyrus and the right middle frontal gyrus as seed regions.Results: In healthy controls, analyses revealed increased activation of the right inferior parietal lobule (mainly the supramarginal gyrus), right insula, and right middle frontal gyrus as an activation of the agency condition. We defined activated Brodmann areas shown in the agency condition of healthy controls as the seed region for connectivity analysis. The connectivity analysis revealed lower connectivity between the head of the left caudate nucleus and right supramarginal gyrus in the patients compared to healthy controls.Conclusions: This dysconnectivity of the agency network in schizophrenia may lead to self-disturbance through deficits in associative learning of SoA. These findings may explain why pathological function of the striatum in schizophrenia leads to self-disturbance. |
topic |
schizophrenia sense of agency self-disturbance functional connectivity imaging caudate |
url |
https://www.frontiersin.org/article/10.3389/fpsyt.2019.00171/full |
work_keys_str_mv |
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doaj-3f1fa57a2d624e7ab15d4c66d2bf2ef32020-11-24T21:59:13ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402019-04-011010.3389/fpsyt.2019.00171434416Dysconnectivity of the Agency Network in Schizophrenia: A Functional Magnetic Resonance Imaging StudyAkihiro Koreki0Akihiro Koreki1Akihiro Koreki2Takaki Maeda3Takaki Maeda4Tsukasa Okimura5Tsukasa Okimura6Yuri Terasawa7Yuri Terasawa8Toshiaki Kikuchi9Satoshi Umeda10Satoshi Umeda11Shiro Nishikata12Shiro Nishikata13Tatsuhiko Yagihashi14Tatsuhiko Yagihashi15Mari Kasahara16Mari Kasahara17Chiyoko Nagai18Chiyoko Nagai19Yasushi Moriyama20Yasushi Moriyama21Ryosuke Den22Ryosuke Den23Tamotsu Watanabe24Tamotsu Watanabe25Hirotsugu Kikumoto26Motoichiro Kato27Motoichiro Kato28Masaru Mimura29Department of Neuropsychiatry, School of Medicine, Keio University, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Neuropsychiatry, National Hospital Organization Shimofusa Psychiatric Medical Center, Chiba, JapanDepartment of Neuropsychiatry, School of Medicine, Keio University, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Neuropsychiatry, School of Medicine, Keio University, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Psychology, Keio University, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Psychology, Keio University, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Psychiatry, Komagino Hospital, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Psychiatry, Komagino Hospital, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Psychiatry, Komagino Hospital, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Speech-Language Pathology and Audiology, Teikyo Heisei University, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Psychiatry, Komagino Hospital, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Psychiatry, Komagino Hospital, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Psychiatry, Komagino Hospital, Tokyo, JapanDepartment of Psychiatry, Komagino Hospital, Tokyo, JapanDepartment of Neuropsychiatry, School of Medicine, Keio University, Tokyo, JapanCenter for Psychiatry and Behavioral Science, Komagino Hospital, Tokyo, JapanDepartment of Neuropsychiatry, School of Medicine, Keio University, Tokyo, JapanBackground: Self-disturbances in schizophrenia have recently been explained by an abnormality in the sense of agency (SoA). The cerebral structures of SoA in healthy people are considered to mainly include the insula and inferior parietal lobule. In contrast, the functional lesion of aberrant SoA in schizophrenia is not yet fully understood. Considering the recent explanation of establishing SoA from the standpoint of associative learning, the “agency network” may include not only the insula and inferior parietal lobule but also the striatum. We hypothesized that aberrant SoA in schizophrenia is based on a deficit in the “agency network.”Methods: Functional magnetic resonance imaging data were acquired while patients with schizophrenia (n = 15) and matched controls (n = 15) performed our adaptation method of agency attribution task on a trial-by-trial basis to assess participants' explicit experience of the temporal causal relationship between an action and an external event with temporal biases. Analysis of functional connectivity was done using the right supramarginal gyrus and the right middle frontal gyrus as seed regions.Results: In healthy controls, analyses revealed increased activation of the right inferior parietal lobule (mainly the supramarginal gyrus), right insula, and right middle frontal gyrus as an activation of the agency condition. We defined activated Brodmann areas shown in the agency condition of healthy controls as the seed region for connectivity analysis. The connectivity analysis revealed lower connectivity between the head of the left caudate nucleus and right supramarginal gyrus in the patients compared to healthy controls.Conclusions: This dysconnectivity of the agency network in schizophrenia may lead to self-disturbance through deficits in associative learning of SoA. These findings may explain why pathological function of the striatum in schizophrenia leads to self-disturbance.https://www.frontiersin.org/article/10.3389/fpsyt.2019.00171/fullschizophreniasense of agencyself-disturbancefunctional connectivityimagingcaudate |