Linked dimensions of psychopathology and connectivity in functional brain networks
Co-morbidity and symptom overlap make it difficult to associate psychiatric disorders with unique neural signatures. Here, the authors use a data-driven approach to show that the symptom dimensions of mood, psychosis, fear and externalizing behavior exhibit unique patterns of functional dysconnectiv...
| Main Authors: | , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Publishing Group
2018-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-018-05317-y |
| id |
doaj-3f26b7217d3b4ddb99ccbd289a6fae95 |
|---|---|
| record_format |
Article |
| spelling |
doaj-3f26b7217d3b4ddb99ccbd289a6fae952021-05-11T09:32:29ZengNature Publishing GroupNature Communications2041-17232018-08-019111410.1038/s41467-018-05317-yLinked dimensions of psychopathology and connectivity in functional brain networksCedric Huchuan Xia0Zongming Ma1Rastko Ciric2Shi Gu3Richard F. Betzel4Antonia N. Kaczkurkin5Monica E. Calkins6Philip A. Cook7Angel García de la Garza8Simon N. Vandekar9Zaixu Cui10Tyler M. Moore11David R. Roalf12Kosha Ruparel13Daniel H. Wolf14Christos Davatzikos15Ruben C. Gur16Raquel E. Gur17Russell T. Shinohara18Danielle S. Bassett19Theodore D. Satterthwaite20Department of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Statistics, The Wharton School, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Bioengineering, School of Engineering and Applied Science, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Radiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Radiology, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaDepartment of Biostatistics, Epidemiology, and Informatics, Perelman School of Medicine, University of PennsylvaniaDepartment of Bioengineering, School of Engineering and Applied Science, University of PennsylvaniaDepartment of Psychiatry, Perelman School of Medicine, University of PennsylvaniaCo-morbidity and symptom overlap make it difficult to associate psychiatric disorders with unique neural signatures. Here, the authors use a data-driven approach to show that the symptom dimensions of mood, psychosis, fear and externalizing behavior exhibit unique patterns of functional dysconnectivity.https://doi.org/10.1038/s41467-018-05317-y |
| collection |
DOAJ |
| language |
English |
| format |
Article |
| sources |
DOAJ |
| author |
Cedric Huchuan Xia Zongming Ma Rastko Ciric Shi Gu Richard F. Betzel Antonia N. Kaczkurkin Monica E. Calkins Philip A. Cook Angel García de la Garza Simon N. Vandekar Zaixu Cui Tyler M. Moore David R. Roalf Kosha Ruparel Daniel H. Wolf Christos Davatzikos Ruben C. Gur Raquel E. Gur Russell T. Shinohara Danielle S. Bassett Theodore D. Satterthwaite |
| spellingShingle |
Cedric Huchuan Xia Zongming Ma Rastko Ciric Shi Gu Richard F. Betzel Antonia N. Kaczkurkin Monica E. Calkins Philip A. Cook Angel García de la Garza Simon N. Vandekar Zaixu Cui Tyler M. Moore David R. Roalf Kosha Ruparel Daniel H. Wolf Christos Davatzikos Ruben C. Gur Raquel E. Gur Russell T. Shinohara Danielle S. Bassett Theodore D. Satterthwaite Linked dimensions of psychopathology and connectivity in functional brain networks Nature Communications |
| author_facet |
Cedric Huchuan Xia Zongming Ma Rastko Ciric Shi Gu Richard F. Betzel Antonia N. Kaczkurkin Monica E. Calkins Philip A. Cook Angel García de la Garza Simon N. Vandekar Zaixu Cui Tyler M. Moore David R. Roalf Kosha Ruparel Daniel H. Wolf Christos Davatzikos Ruben C. Gur Raquel E. Gur Russell T. Shinohara Danielle S. Bassett Theodore D. Satterthwaite |
| author_sort |
Cedric Huchuan Xia |
| title |
Linked dimensions of psychopathology and connectivity in functional brain networks |
| title_short |
Linked dimensions of psychopathology and connectivity in functional brain networks |
| title_full |
Linked dimensions of psychopathology and connectivity in functional brain networks |
| title_fullStr |
Linked dimensions of psychopathology and connectivity in functional brain networks |
| title_full_unstemmed |
Linked dimensions of psychopathology and connectivity in functional brain networks |
| title_sort |
linked dimensions of psychopathology and connectivity in functional brain networks |
| publisher |
Nature Publishing Group |
| series |
Nature Communications |
| issn |
2041-1723 |
| publishDate |
2018-08-01 |
| description |
Co-morbidity and symptom overlap make it difficult to associate psychiatric disorders with unique neural signatures. Here, the authors use a data-driven approach to show that the symptom dimensions of mood, psychosis, fear and externalizing behavior exhibit unique patterns of functional dysconnectivity. |
| url |
https://doi.org/10.1038/s41467-018-05317-y |
| work_keys_str_mv |
AT cedrichuchuanxia linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT zongmingma linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT rastkociric linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT shigu linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT richardfbetzel linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT antoniankaczkurkin linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT monicaecalkins linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT philipacook linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT angelgarciadelagarza linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT simonnvandekar linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT zaixucui linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT tylermmoore linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT davidrroalf linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT kosharuparel linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT danielhwolf linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT christosdavatzikos linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT rubencgur linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT raquelegur linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT russelltshinohara linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT daniellesbassett linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks AT theodoredsatterthwaite linkeddimensionsofpsychopathologyandconnectivityinfunctionalbrainnetworks |
| _version_ |
1721449634311700480 |