Activation of the Nrf2/HO-1 Signaling Pathway Contributes to the Protective Effects of Sargassum serratifolium Extract against Oxidative Stress-Induced DNA Damage and Apoptosis in SW1353 Human Chondrocytes

Activation of the Nrf2/HO-1 Signaling Pathway Contributes to the Protective Effects of Sargassum serratifolium Extract against Oxidative Stress-Induced DNA Damage and Apoptosis in SW1353 Human Chondrocytes

Oxidative stress in chondrocytes plays a critical role in the pathogenesis of osteoarthritis as an important cause of articular cartilage degradation. Sargassum serratifolium C. Agardh, a marine brown algae, is known to have potent antioxidant activity. Nevertheless, no study has been conducted yet...

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Bibliographic Details
Main Authors: Cheol Park, Su Hyun Hong, Soon Shik Shin, Dae-Sung Lee, Min Ho Han, Hee-Jae Cha, Suhkmann Kim, Heui-Soo Kim, Gi-Young Kim, Eui Kyun Park, You-Jin Jeon, Yung Hyun Choi
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:International Journal of Environmental Research and Public Health
Subjects:
Sargassum serratifolium C. Agardh
chondrocytes
oxidative stress
apoptosis
Nrf2/HO-1
Online Access:http://www.mdpi.com/1660-4601/15/6/1173

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http://www.mdpi.com/1660-4601/15/6/1173

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