Interaction between Parkin and <i>α</i>-Synuclein in <i>PARK2</i>-Mediated Parkinson’s Disease

Interaction between Parkin and <i>α</i>-Synuclein in <i>PARK2</i>-Mediated Parkinson’s Disease

Parkin and <i>α</i>-synuclein are two key proteins involved in the pathophysiology of Parkinson’s disease (PD). Neurotoxic alterations of <i>α</i>-synuclein that lead to the formation of toxic oligomers and fibrils contribute to PD through synaptic dysfunction, mitochondrial...

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Bibliographic Details
Main Authors: Daniel Aghaie Madsen, Sissel Ida Schmidt, Morten Blaabjerg, Morten Meyer
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:Cells
Subjects:
familial Parkinson’s disease
<i>PARK2</i>
parkin
<i>α</i>-synuclein
Lewy bodies
Online Access:https://www.mdpi.com/2073-4409/10/2/283

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