Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i>

Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i>

Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (<b>8</b>), were isolated from the dichloromethane extract of the roots of <i>Heptaptera anatolica</i>. Structures of these compounds were elucidated based on their spectral properties. While som...

Full description

Bibliographic Details
Main Authors: Fatma Tosun, John A. Beutler, Tanya T. Ransom, Mahmut Miski
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:Molecules
Subjects:
<i>Heptaptera anatolica</i>
Apiaceae
sesquiterpene coumarins
cytotoxic activity
Online Access:https://www.mdpi.com/1420-3049/24/6/1153
Description
Summary:Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (<b>8</b>), were isolated from the dichloromethane extract of the roots of <i>Heptaptera anatolica</i>. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (<b>8</b>) and 14&#8242;-acetoxybadrakemin (<b>7</b>) were observed at nanomolar level against the UO31 kidney cancer cell line.
ISSN:1420-3049

Similar Items