Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of Heptaptera anatolica

Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (8), were isolated from the dichloromethane extract of the roots of Heptaptera anatolica. Structures of these compounds were elucidated based on their spectral properties. While som...

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Bibliographic Details
Main Authors:	Fatma Tosun, John A. Beutler, Tanya T. Ransom, Mahmut Miski
Format:	Article
Language:	English
Published:	MDPI AG 2019-03-01
Series:	Molecules
Subjects:	<i>Heptaptera anatolica</i> Apiaceae sesquiterpene coumarins cytotoxic activity
Online Access:	https://www.mdpi.com/1420-3049/24/6/1153

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spelling	doaj-3f353ec9e74e4ec9a8a083fe9197409d2020-11-24T20:54:35ZengMDPI AGMolecules1420-30492019-03-01246115310.3390/molecules24061153molecules24061153Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i>Fatma Tosun0John A. Beutler1Tanya T. Ransom2Mahmut Miski3Department of Pharmacognosy, School of Pharmacy, Istanbul Medipol University, Istanbul 34810, TurkeyMolecular Targets Program, CCR, NCI, Frederick, MD 21702, USAMolecular Targets Program, CCR, NCI, Frederick, MD 21702, USADepartment of Pharmacognosy, Faculty of Pharmacy, Istanbul University, Istanbul 34116, TurkeySeven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (<b>8</b>), were isolated from the dichloromethane extract of the roots of <i>Heptaptera anatolica</i>. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (<b>8</b>) and 14′-acetoxybadrakemin (<b>7</b>) were observed at nanomolar level against the UO31 kidney cancer cell line.https://www.mdpi.com/1420-3049/24/6/1153<i>Heptaptera anatolica</i>Apiaceaesesquiterpene coumarinscytotoxic activity
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Fatma Tosun John A. Beutler Tanya T. Ransom Mahmut Miski
spellingShingle	Fatma Tosun John A. Beutler Tanya T. Ransom Mahmut Miski Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i> Molecules <i>Heptaptera anatolica</i> Apiaceae sesquiterpene coumarins cytotoxic activity
author_facet	Fatma Tosun John A. Beutler Tanya T. Ransom Mahmut Miski
author_sort	Fatma Tosun
title	Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i>
title_short	Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i>
title_full	Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i>
title_fullStr	Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i>
title_full_unstemmed	Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i>
title_sort	anatolicin, a highly potent and selective cytotoxic sesquiterpene coumarin from the root extract of <i>heptaptera anatolica</i>
publisher	MDPI AG
series	Molecules
issn	1420-3049
publishDate	2019-03-01
description	Seven known sesquiterpene coumarins and a new sesquiterpene coumarin, anatolicin (<b>8</b>), were isolated from the dichloromethane extract of the roots of <i>Heptaptera anatolica</i>. Structures of these compounds were elucidated based on their spectral properties. While some of these sesquiterpene coumarins showed modest cytotoxic activity against COLO205, KM12, A498, UO31, and TC32 cancer cell lines, selective cytotoxicity of anatolicin (<b>8</b>) and 14′-acetoxybadrakemin (<b>7</b>) were observed at nanomolar level against the UO31 kidney cancer cell line.
topic	<i>Heptaptera anatolica</i> Apiaceae sesquiterpene coumarins cytotoxic activity
url	https://www.mdpi.com/1420-3049/24/6/1153
work_keys_str_mv	AT fatmatosun anatolicinahighlypotentandselectivecytotoxicsesquiterpenecoumarinfromtherootextractofiheptapteraanatolicai AT johnabeutler anatolicinahighlypotentandselectivecytotoxicsesquiterpenecoumarinfromtherootextractofiheptapteraanatolicai AT tanyatransom anatolicinahighlypotentandselectivecytotoxicsesquiterpenecoumarinfromtherootextractofiheptapteraanatolicai AT mahmutmiski anatolicinahighlypotentandselectivecytotoxicsesquiterpenecoumarinfromtherootextractofiheptapteraanatolicai
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Anatolicin, a Highly Potent and Selective Cytotoxic Sesquiterpene Coumarin from the Root Extract of <i>Heptaptera anatolica</i>

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