Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination
Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-cent...
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Format: | Article |
Language: | English |
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MDPI AG
2019-08-01
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Series: | Journal of Clinical Medicine |
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Online Access: | https://www.mdpi.com/2077-0383/8/9/1320 |
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Article |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kazumasa Oda Hideshi Okada Akio Suzuki Hiroyuki Tomita Ryo Kobayashi Kazuyuki Sumi Kodai Suzuki Chihiro Takada Takuma Ishihara Keiko Suzuki Soichiro Kano Kohei Kondo Yuki Iwashita Hirohisa Yano Ryogen Zaikokuji So Sampei Tetsuya Fukuta Yuichiro Kitagawa Haruka Okamoto Takatomo Watanabe Tomonori Kawaguchi Takao Kojima Fumiko Deguchi Nagisa Miyazaki Noriaki Yamada Tomoaki Doi Takahiro Yoshida Hiroaki Ushikoshi Shozo Yoshida Genzou Takemura Shinji Ogura |
spellingShingle |
Kazumasa Oda Hideshi Okada Akio Suzuki Hiroyuki Tomita Ryo Kobayashi Kazuyuki Sumi Kodai Suzuki Chihiro Takada Takuma Ishihara Keiko Suzuki Soichiro Kano Kohei Kondo Yuki Iwashita Hirohisa Yano Ryogen Zaikokuji So Sampei Tetsuya Fukuta Yuichiro Kitagawa Haruka Okamoto Takatomo Watanabe Tomonori Kawaguchi Takao Kojima Fumiko Deguchi Nagisa Miyazaki Noriaki Yamada Tomoaki Doi Takahiro Yoshida Hiroaki Ushikoshi Shozo Yoshida Genzou Takemura Shinji Ogura Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination Journal of Clinical Medicine endothelial disorders glycocalyx injury syndecan-1 nonlinear regression |
author_facet |
Kazumasa Oda Hideshi Okada Akio Suzuki Hiroyuki Tomita Ryo Kobayashi Kazuyuki Sumi Kodai Suzuki Chihiro Takada Takuma Ishihara Keiko Suzuki Soichiro Kano Kohei Kondo Yuki Iwashita Hirohisa Yano Ryogen Zaikokuji So Sampei Tetsuya Fukuta Yuichiro Kitagawa Haruka Okamoto Takatomo Watanabe Tomonori Kawaguchi Takao Kojima Fumiko Deguchi Nagisa Miyazaki Noriaki Yamada Tomoaki Doi Takahiro Yoshida Hiroaki Ushikoshi Shozo Yoshida Genzou Takemura Shinji Ogura |
author_sort |
Kazumasa Oda |
title |
Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination |
title_short |
Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination |
title_full |
Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination |
title_fullStr |
Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination |
title_full_unstemmed |
Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical Examination |
title_sort |
factors enhancing serum syndecan-1 concentrations: a large-scale comprehensive medical examination |
publisher |
MDPI AG |
series |
Journal of Clinical Medicine |
issn |
2077-0383 |
publishDate |
2019-08-01 |
description |
Endothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018 to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by the collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (<i>p</i> = 0.016), aspartic aminotransferase concentration (AST, <i>p</i> = 0.020), blood urea nitrogen concentration (BUN, <i>p</i> = 0.013), triglyceride concentration (<i>p</i> < 0.001), and hematocrit (<i>p</i> = 0.006). These relationships were independent associations. Endothelial glycocalyx injury, which is reflected by serum syndecan-1 concentrations, is related to age, hematocrit, AST concentration, BUN concentration, and triglyceride concentration. |
topic |
endothelial disorders glycocalyx injury syndecan-1 nonlinear regression |
url |
https://www.mdpi.com/2077-0383/8/9/1320 |
work_keys_str_mv |
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doaj-3f36f896f7884cc7a63f6ca5272f7ba92020-11-25T01:21:38ZengMDPI AGJournal of Clinical Medicine2077-03832019-08-0189132010.3390/jcm8091320jcm8091320Factors Enhancing Serum Syndecan-1 Concentrations: A Large-Scale Comprehensive Medical ExaminationKazumasa Oda0Hideshi Okada1Akio Suzuki2Hiroyuki Tomita3Ryo Kobayashi4Kazuyuki Sumi5Kodai Suzuki6Chihiro Takada7Takuma Ishihara8Keiko Suzuki9Soichiro Kano10Kohei Kondo11Yuki Iwashita12Hirohisa Yano13Ryogen Zaikokuji14So Sampei15Tetsuya Fukuta16Yuichiro Kitagawa17Haruka Okamoto18Takatomo Watanabe19Tomonori Kawaguchi20Takao Kojima21Fumiko Deguchi22Nagisa Miyazaki23Noriaki Yamada24Tomoaki Doi25Takahiro Yoshida26Hiroaki Ushikoshi27Shozo Yoshida28Genzou Takemura29Shinji Ogura30Department of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Pharmacy, Gifu University Hospital, Gifu 501-1194, JapanDepartment of Tumor Pathology, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Pharmacy, Gifu University Hospital, Gifu 501-1194, JapanDepartment of Pharmacy, Gifu University Hospital, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanInnovative and Clinical Research Promotion Center, Gifu University Hospital, Gifu 501-1194, JapanDepartment of Pharmacy, Gifu University Hospital, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Clinical Laboratory, Gifu University Hospital, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanMedical Health Check-up Center, Asahi University Hospital, Gifu 500-8523, JapanMedical Health Check-up Center, Asahi University Hospital, Gifu 500-8523, JapanDepartment of Internal Medicine, Asahi University School of Dentistry, Mizuho 501-0223, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanDepartment of Internal Medicine, Asahi University School of Dentistry, Mizuho 501-0223, JapanDepartment of Emergency and Disaster Medicine, Gifu University Graduate School of Medicine, Gifu 501-1194, JapanEndothelial disorders are related to various diseases. An initial endothelial injury is characterized by endothelial glycocalyx injury. We aimed to evaluate endothelial glycocalyx injury by measuring serum syndecan-1 concentrations in patients during comprehensive medical examinations. A single-center, prospective, observational study was conducted at Asahi University Hospital. The participants enrolled in this study were 1313 patients who underwent comprehensive medical examinations at Asahi University Hospital from January 2018 to June 2018. One patient undergoing hemodialysis was excluded from the study. At enrollment, blood samples were obtained, and study personnel collected demographic and clinical data. No treatments or exposures were conducted except for standard medical examinations and blood sample collection. Laboratory data were obtained by the collection of blood samples at the time of study enrolment. According to nonlinear regression, the concentrations of serum syndecan-1 were significantly related to age (<i>p</i> = 0.016), aspartic aminotransferase concentration (AST, <i>p</i> = 0.020), blood urea nitrogen concentration (BUN, <i>p</i> = 0.013), triglyceride concentration (<i>p</i> < 0.001), and hematocrit (<i>p</i> = 0.006). These relationships were independent associations. Endothelial glycocalyx injury, which is reflected by serum syndecan-1 concentrations, is related to age, hematocrit, AST concentration, BUN concentration, and triglyceride concentration.https://www.mdpi.com/2077-0383/8/9/1320endothelial disordersglycocalyx injurysyndecan-1nonlinear regression |