An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>

An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>

The discovery of eco-friendly, rapid, and cost-effective compounds to control diseases caused by microbes and insects are the main challenges. Herein, the magnesium oxide nanoparticles (MgO-NPs) are successfully fabricated by harnessing the metabolites secreted by <i>Penicillium chrysogenum<...

Full description

Bibliographic Details
Main Authors: Amr Fouda, Mohamed A. Awad, Ahmed M. Eid, Ebrahim Saied, Mohammed G. Barghoth, Mohammed F. Hamza, Mohamed F. Awad, Salah Abdelbary, Saad El-Din Hassan
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:International Journal of Molecular Sciences
Subjects:
green synthesis
MgO-NPs
pathogenic microbes
<i>Anopheles stephensi</i>
biocontrol
mosquitocidal
Online Access:https://www.mdpi.com/1422-0067/22/10/5096
id doaj-3f3781806d2f46b7b1d33dc56d6b1385
record_format Article
spelling doaj-3f3781806d2f46b7b1d33dc56d6b13852021-05-31T23:45:43ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672021-05-01225096509610.3390/ijms22105096An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>Amr Fouda0Mohamed A. Awad1Ahmed M. Eid2Ebrahim Saied3Mohammed G. Barghoth4Mohammed F. Hamza5Mohamed F. Awad6Salah Abdelbary7Saad El-Din Hassan8Department of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Zoology and Entomology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptGuangxi Key Laboratory of Processing for Non-Ferrous Metals and Featured Materials, School of Resources, Environment and Materials, Guangxi University, Nanning 530004, ChinaDepartment of Biology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi ArabiaDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptDepartment of Botany and Microbiology, Faculty of Science, Al-Azhar University, Nasr City, Cairo 11884, EgyptThe discovery of eco-friendly, rapid, and cost-effective compounds to control diseases caused by microbes and insects are the main challenges. Herein, the magnesium oxide nanoparticles (MgO-NPs) are successfully fabricated by harnessing the metabolites secreted by <i>Penicillium chrysogenum</i>. The fabricated MgO-NPs were characterized using UV-Vis, XRD, TEM, DLS, EDX, FT-IR, and XPS analyses. Data showed the successful formation of crystallographic, spherical, well-dispersed MgO-NPs with sizes of 7–40 nm at a maximum wavelength of 250 nm. The EDX analysis confirms the presence of Mg and O ions as the main components with weight percentages of 13.62% and 7.76%, respectively. The activity of MgO-NPs as an antimicrobial agent was investigated against pathogens <i>Staphylococcus aureus</i>, <i>Bacillus subtilis</i>, <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Candida albicans</i>, and exhibited zone of inhibitions of 12.0 ± 0.0, 12.7 ± 0.9, 23.3 ± 0.8, 17.7 ± 1.6, and 14.7 ± 0.6 mm respectively, at 200 µg mL<sup>−1</sup>. The activity is decreased by decreasing the MgO-NPs concentration. The biogenic MgO-NPs exhibit high efficacy against different larvae instar and pupa of <i>Anopheles stephensi</i>, with LC50 values of 12.5–15.5 ppm for I–IV larvae instar and 16.5 ppm for the pupa. Additionally, 5 mg/cm<sup>2</sup> of MgO-NPs showed the highest protection percentages against adults of <i>Anopheles stephensi</i>, with values of 100% for 150 min and 67.6% ± 1.4% for 210 min.https://www.mdpi.com/1422-0067/22/10/5096green synthesisMgO-NPspathogenic microbes<i>Anopheles stephensi</i>biocontrolmosquitocidal
collection DOAJ
language English
format Article
sources DOAJ
author Amr Fouda
Mohamed A. Awad
Ahmed M. Eid
Ebrahim Saied
Mohammed G. Barghoth
Mohammed F. Hamza
Mohamed F. Awad
Salah Abdelbary
Saad El-Din Hassan
spellingShingle Amr Fouda
Mohamed A. Awad
Ahmed M. Eid
Ebrahim Saied
Mohammed G. Barghoth
Mohammed F. Hamza
Mohamed F. Awad
Salah Abdelbary
Saad El-Din Hassan
An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>
International Journal of Molecular Sciences
green synthesis
MgO-NPs
pathogenic microbes
<i>Anopheles stephensi</i>
biocontrol
mosquitocidal
author_facet Amr Fouda
Mohamed A. Awad
Ahmed M. Eid
Ebrahim Saied
Mohammed G. Barghoth
Mohammed F. Hamza
Mohamed F. Awad
Salah Abdelbary
Saad El-Din Hassan
author_sort Amr Fouda
title An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>
title_short An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>
title_full An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>
title_fullStr An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>
title_full_unstemmed An Eco-Friendly Approach to the Control of Pathogenic Microbes and <i>Anopheles stephensi</i> Malarial Vector Using Magnesium Oxide Nanoparticles (Mg-NPs) Fabricated by <i>Penicillium chrysogenum</i>
title_sort eco-friendly approach to the control of pathogenic microbes and <i>anopheles stephensi</i> malarial vector using magnesium oxide nanoparticles (mg-nps) fabricated by <i>penicillium chrysogenum</i>
publisher MDPI AG
series International Journal of Molecular Sciences
issn 1661-6596
1422-0067
publishDate 2021-05-01
description The discovery of eco-friendly, rapid, and cost-effective compounds to control diseases caused by microbes and insects are the main challenges. Herein, the magnesium oxide nanoparticles (MgO-NPs) are successfully fabricated by harnessing the metabolites secreted by <i>Penicillium chrysogenum</i>. The fabricated MgO-NPs were characterized using UV-Vis, XRD, TEM, DLS, EDX, FT-IR, and XPS analyses. Data showed the successful formation of crystallographic, spherical, well-dispersed MgO-NPs with sizes of 7–40 nm at a maximum wavelength of 250 nm. The EDX analysis confirms the presence of Mg and O ions as the main components with weight percentages of 13.62% and 7.76%, respectively. The activity of MgO-NPs as an antimicrobial agent was investigated against pathogens <i>Staphylococcus aureus</i>, <i>Bacillus subtilis</i>, <i>Pseudomonas aeruginosa</i>, <i>Escherichia coli</i>, and <i>Candida albicans</i>, and exhibited zone of inhibitions of 12.0 ± 0.0, 12.7 ± 0.9, 23.3 ± 0.8, 17.7 ± 1.6, and 14.7 ± 0.6 mm respectively, at 200 µg mL<sup>−1</sup>. The activity is decreased by decreasing the MgO-NPs concentration. The biogenic MgO-NPs exhibit high efficacy against different larvae instar and pupa of <i>Anopheles stephensi</i>, with LC50 values of 12.5–15.5 ppm for I–IV larvae instar and 16.5 ppm for the pupa. Additionally, 5 mg/cm<sup>2</sup> of MgO-NPs showed the highest protection percentages against adults of <i>Anopheles stephensi</i>, with values of 100% for 150 min and 67.6% ± 1.4% for 210 min.
topic green synthesis
MgO-NPs
pathogenic microbes
<i>Anopheles stephensi</i>
biocontrol
mosquitocidal
url https://www.mdpi.com/1422-0067/22/10/5096
work_keys_str_mv AT amrfouda anecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT mohamedaawad anecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT ahmedmeid anecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT ebrahimsaied anecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT mohammedgbarghoth anecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT mohammedfhamza anecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT mohamedfawad anecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT salahabdelbary anecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT saadeldinhassan anecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT amrfouda ecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT mohamedaawad ecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT ahmedmeid ecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT ebrahimsaied ecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT mohammedgbarghoth ecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT mohammedfhamza ecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT mohamedfawad ecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT salahabdelbary ecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
AT saadeldinhassan ecofriendlyapproachtothecontrolofpathogenicmicrobesandianophelesstephensiimalarialvectorusingmagnesiumoxidenanoparticlesmgnpsfabricatedbyipenicilliumchrysogenumi
_version_ 1721416706650275840

Similar Items