Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis.
This study evaluated bacterial etiology and antibiotic susceptibility in patients diagnosed with community-acquired perforated appendicitis over a 12-year-period. We retrospectively reviewed records of adult patients diagnosed with perforated appendicitis at an 800-bed teaching hospital between Janu...
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doaj-3f42192662aa4b3db0758888d64a49882020-11-25T01:39:13ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-01910e11114410.1371/journal.pone.0111144Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis.Hong Gil JeonHyeong Uk JuGyu Yeol KimJoseph JeongMin-Ho KimJae-Bum JunThis study evaluated bacterial etiology and antibiotic susceptibility in patients diagnosed with community-acquired perforated appendicitis over a 12-year-period. We retrospectively reviewed records of adult patients diagnosed with perforated appendicitis at an 800-bed teaching hospital between January 2000 and December 2011. In total, 415 culture-positive perforated appendicitis cases were analyzed. Escherichia coli was the most common pathogen (277/415, 66.7%), followed by Streptococcus species (61/415, 14.7%). The susceptibility of E. coli to ampicillin, piperacillin/tazobactam, ceftriaxone, cefepime, amikacin, gentamicin, and imipenem was 35.1%, 97.1%, 97.0%, 98.2%, 98.9%, 81.8%, and 100%, respectively. The overall susceptibility of E. coli to quinolones (ciprofloxacin or levofloxacin) was 78.7%. During the study period, univariate logistic regression analysis showed a significant decrease in E. coli susceptibility to quinolones (OR = 0.91, 95% CI 0.84-0.99, P = 0.040). We therefore do not recommend quinolones as empirical therapy for community-acquired perforated appendicitis.http://europepmc.org/articles/PMC4208803?pdf=render |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Hong Gil Jeon Hyeong Uk Ju Gyu Yeol Kim Joseph Jeong Min-Ho Kim Jae-Bum Jun |
spellingShingle |
Hong Gil Jeon Hyeong Uk Ju Gyu Yeol Kim Joseph Jeong Min-Ho Kim Jae-Bum Jun Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis. PLoS ONE |
author_facet |
Hong Gil Jeon Hyeong Uk Ju Gyu Yeol Kim Joseph Jeong Min-Ho Kim Jae-Bum Jun |
author_sort |
Hong Gil Jeon |
title |
Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis. |
title_short |
Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis. |
title_full |
Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis. |
title_fullStr |
Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis. |
title_full_unstemmed |
Bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis. |
title_sort |
bacteriology and changes in antibiotic susceptibility in adults with community-acquired perforated appendicitis. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2014-01-01 |
description |
This study evaluated bacterial etiology and antibiotic susceptibility in patients diagnosed with community-acquired perforated appendicitis over a 12-year-period. We retrospectively reviewed records of adult patients diagnosed with perforated appendicitis at an 800-bed teaching hospital between January 2000 and December 2011. In total, 415 culture-positive perforated appendicitis cases were analyzed. Escherichia coli was the most common pathogen (277/415, 66.7%), followed by Streptococcus species (61/415, 14.7%). The susceptibility of E. coli to ampicillin, piperacillin/tazobactam, ceftriaxone, cefepime, amikacin, gentamicin, and imipenem was 35.1%, 97.1%, 97.0%, 98.2%, 98.9%, 81.8%, and 100%, respectively. The overall susceptibility of E. coli to quinolones (ciprofloxacin or levofloxacin) was 78.7%. During the study period, univariate logistic regression analysis showed a significant decrease in E. coli susceptibility to quinolones (OR = 0.91, 95% CI 0.84-0.99, P = 0.040). We therefore do not recommend quinolones as empirical therapy for community-acquired perforated appendicitis. |
url |
http://europepmc.org/articles/PMC4208803?pdf=render |
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