Recent advances in dynamic m6A RNA modification

• Main Authors: Guangchao Cao, Hua-Bing Li, Zhinan Yin, Richard A. Flavell
• Format: Article
• Language: English
• Published: The Royal Society 2016-01-01
• Series: Open Biology
• Subjects: m6a; mrna; methylation
• Online Access: https://royalsocietypublishing.org/doi/pdf/10.1098/rsob.160003

The identification of m6A demethylases and high-throughput sequencing analysis of methylated transcriptome corroborated m6A RNA epigenetic modification as a dynamic regulation process, and reignited its investigation in the past few years. Many basic concepts of cytogenetics have been revolutionized by the growing understanding of the fundamental role of m6A in RNA splicing, degradation and translation. In this review, we summarize typical features of methylated transcriptome in mammals, and highlight the ‘writers’, ‘erasers’ and ‘readers’ of m6A RNA modification. Moreover, we emphasize recent advances of biological functions of m6A and conceive the possible roles of m6A in the regulation of immune response and related diseases.