Oral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications
Abstract Background Few studies focused on longitudinal modifications over time of high-risk HPV (HR-HPV) at anal and oral sites in HIV+ men who have sex with men (MSM). Methods We described patterns and longitudinal changes of HR-HPV detection and the prevalence of HR-HPV covered by the nonavalent...
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doaj-3f4ebe17a224438face1b4a9f3f9e29a2020-11-25T03:18:09ZengBMCBMC Public Health1471-24582019-05-0119111110.1186/s12889-019-7004-xOral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implicationsSaverio Giuseppe Parisi0Monica Basso1Renzo Scaggiante2Samantha Andreis3Carlo Mengoli4Mario Cruciani5Claudia Del Vecchio6Nicola Menegotto7Daniela Zago8Loredana Sarmati9Massimo Andreoni10Giorgio Palù11Department of Molecular Medicine, University of PadovaDepartment of Molecular Medicine, University of PadovaInfectious Diseases Unit, Padova HospitalDepartment of Molecular Medicine, University of PadovaDepartment of Molecular Medicine, University of PadovaCenter of Diffusive DiseasesDepartment of Molecular Medicine, University of PadovaDepartment of Molecular Medicine, University of PadovaDepartment of Molecular Medicine, University of PadovaClinical Infectious Diseases, Tor Vergata UniversityClinical Infectious Diseases, Tor Vergata UniversityDepartment of Molecular Medicine, University of PadovaAbstract Background Few studies focused on longitudinal modifications over time of high-risk HPV (HR-HPV) at anal and oral sites in HIV+ men who have sex with men (MSM). Methods We described patterns and longitudinal changes of HR-HPV detection and the prevalence of HR-HPV covered by the nonavalent HPV vaccine (vax-HPV) at oral and anal sites in 165 HIV+ MSM followed in an Italian hospital. The samples were collected at baseline and after 24 months (follow-up). The presence of HPV was investigated with Inno-LiPA HPV Genotyping Extra II. Results Median age was 44 years (IQR 36–53), median CD4+ cell count at nadir was 312 cells/mm3 (IQR 187–450). A total of 120 subjects (72.7%) were receiving successful antiretroviral therapy (ART). At baseline and follow-up, the frequency of HR-HPV was significantly higher in the anal site (65.4% vs 9.4 and 62.4% vs 6.8%, respectively). Only 2.9% of subjects were persistently HR-HPV negative at both sites. All oral HR-HPV were single at baseline vs 54.6% at baseline at the anal site (p = 0.005), and all oral HR-HPV were single at follow-up vs 54.4% at anal site at follow-up (p = 0.002). The lowest rate of concordance between the oral and anal results was found for HR-HPV detection; almost all HR-HPV positive results at both anal and oral sites had different HR-HPV.The most frequent HR-HPV in anal swabs at baseline and follow-up were HPV-16 and HPV-52.At follow-up at anal site, 37.5% of patients had different HR-HPV genotypes respect to baseline, 28.8% of subjects with 1 HR-HPV at baseline had an increased number of HR-HPV, and patients on ART showed a lower frequency of confirmed anal HR-HPV detection than untreated patients (p = 0.03) over time. Additionally,54.6 and 50.5% of patients had only HR-vax-HPV at anal site at baseline and follow-up, respectively; 15.2% had only HR-vax-HPV at baseline and follow-up. Conclusions We believe that it is important testing multiple sites over time in HIV-positive MSM. ART seems to protect men from anal HR-HPV confirmed detection. Vaccination programmes could reduce the number of HR-HPV genotypes at anal site and the risk of the first HR-HPV acquisition at the oral site.http://link.springer.com/article/10.1186/s12889-019-7004-xHigh risk HPVMen who have sex with menAnalOralHIV infection |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Saverio Giuseppe Parisi Monica Basso Renzo Scaggiante Samantha Andreis Carlo Mengoli Mario Cruciani Claudia Del Vecchio Nicola Menegotto Daniela Zago Loredana Sarmati Massimo Andreoni Giorgio Palù |
spellingShingle |
Saverio Giuseppe Parisi Monica Basso Renzo Scaggiante Samantha Andreis Carlo Mengoli Mario Cruciani Claudia Del Vecchio Nicola Menegotto Daniela Zago Loredana Sarmati Massimo Andreoni Giorgio Palù Oral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications BMC Public Health High risk HPV Men who have sex with men Anal Oral HIV infection |
author_facet |
Saverio Giuseppe Parisi Monica Basso Renzo Scaggiante Samantha Andreis Carlo Mengoli Mario Cruciani Claudia Del Vecchio Nicola Menegotto Daniela Zago Loredana Sarmati Massimo Andreoni Giorgio Palù |
author_sort |
Saverio Giuseppe Parisi |
title |
Oral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications |
title_short |
Oral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications |
title_full |
Oral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications |
title_fullStr |
Oral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications |
title_full_unstemmed |
Oral and anal high-risk human papilloma virus infection in HIV-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications |
title_sort |
oral and anal high-risk human papilloma virus infection in hiv-positive men who have sex with men over a 24-month longitudinal study: complexity and vaccine implications |
publisher |
BMC |
series |
BMC Public Health |
issn |
1471-2458 |
publishDate |
2019-05-01 |
description |
Abstract Background Few studies focused on longitudinal modifications over time of high-risk HPV (HR-HPV) at anal and oral sites in HIV+ men who have sex with men (MSM). Methods We described patterns and longitudinal changes of HR-HPV detection and the prevalence of HR-HPV covered by the nonavalent HPV vaccine (vax-HPV) at oral and anal sites in 165 HIV+ MSM followed in an Italian hospital. The samples were collected at baseline and after 24 months (follow-up). The presence of HPV was investigated with Inno-LiPA HPV Genotyping Extra II. Results Median age was 44 years (IQR 36–53), median CD4+ cell count at nadir was 312 cells/mm3 (IQR 187–450). A total of 120 subjects (72.7%) were receiving successful antiretroviral therapy (ART). At baseline and follow-up, the frequency of HR-HPV was significantly higher in the anal site (65.4% vs 9.4 and 62.4% vs 6.8%, respectively). Only 2.9% of subjects were persistently HR-HPV negative at both sites. All oral HR-HPV were single at baseline vs 54.6% at baseline at the anal site (p = 0.005), and all oral HR-HPV were single at follow-up vs 54.4% at anal site at follow-up (p = 0.002). The lowest rate of concordance between the oral and anal results was found for HR-HPV detection; almost all HR-HPV positive results at both anal and oral sites had different HR-HPV.The most frequent HR-HPV in anal swabs at baseline and follow-up were HPV-16 and HPV-52.At follow-up at anal site, 37.5% of patients had different HR-HPV genotypes respect to baseline, 28.8% of subjects with 1 HR-HPV at baseline had an increased number of HR-HPV, and patients on ART showed a lower frequency of confirmed anal HR-HPV detection than untreated patients (p = 0.03) over time. Additionally,54.6 and 50.5% of patients had only HR-vax-HPV at anal site at baseline and follow-up, respectively; 15.2% had only HR-vax-HPV at baseline and follow-up. Conclusions We believe that it is important testing multiple sites over time in HIV-positive MSM. ART seems to protect men from anal HR-HPV confirmed detection. Vaccination programmes could reduce the number of HR-HPV genotypes at anal site and the risk of the first HR-HPV acquisition at the oral site. |
topic |
High risk HPV Men who have sex with men Anal Oral HIV infection |
url |
http://link.springer.com/article/10.1186/s12889-019-7004-x |
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