Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated Microbes

Autism spectrum disorder (ASD), which now affects 1 in 59 children in the United States, is known to have comorbidity with gut disorders of a variety of types; however, the link to the microbiome remains poorly characterized. Recent work has provided compelling evidence to link the gut mi...

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Main Authors:	Maude M. David, Christine Tataru, Jena Daniels, Jessey Schwartz, Jessica Keating, Jarrad Hampton-Marcell, Neil Gottel, Jack A. Gilbert, Dennis P. Wall
Format:	Article
Language:	English
Published:	American Society for Microbiology 2021-04-01
Series:	mSystems
Online Access:	https://journals.asm.org/doi/10.1128/mSystems.00193-20

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spelling	doaj-3f545ff85d284708989ba10039ce132a2021-09-21T20:42:23ZengAmerican Society for MicrobiologymSystems2379-50772021-04-016210.1128/mSystems.00193-20Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated MicrobesMaude M. David0https://orcid.org/0000-0003-1561-418XChristine Tataru1Jena Daniels2Jessey Schwartz3Jessica Keating4Jarrad Hampton-Marcell5Neil Gottel6Jack A. Gilbert7Dennis P. Wall8Department of Pediatrics, Division of Systems Medicine, Stanford University, Stanford, California, USADepartment of Pediatrics, Division of Systems Medicine, Stanford University, Stanford, California, USADepartment of Pediatrics, Division of Systems Medicine, Stanford University, Stanford, California, USADepartment of Pediatrics, Division of Systems Medicine, Stanford University, Stanford, California, USADepartment of Pediatrics, Division of Systems Medicine, Stanford University, Stanford, California, USABioscience Division, The Microbiome Center, Argonne National Laboratory, Argonne, Illinois, USABioscience Division, The Microbiome Center, Argonne National Laboratory, Argonne, Illinois, USABioscience Division, The Microbiome Center, Argonne National Laboratory, Argonne, Illinois, USADepartment of Pediatrics, Division of Systems Medicine, Stanford University, Stanford, California, USA Autism spectrum disorder (ASD), which now affects 1 in 59 children in the United States, is known to have comorbidity with gut disorders of a variety of types; however, the link to the microbiome remains poorly characterized. Recent work has provided compelling evidence to link the gut microbiome to the autism phenotype in mouse models, but identification of specific taxa associated with autism has suffered replicability issues in humans.https://journals.asm.org/doi/10.1128/mSystems.00193-20
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Maude M. David Christine Tataru Jena Daniels Jessey Schwartz Jessica Keating Jarrad Hampton-Marcell Neil Gottel Jack A. Gilbert Dennis P. Wall
spellingShingle	Maude M. David Christine Tataru Jena Daniels Jessey Schwartz Jessica Keating Jarrad Hampton-Marcell Neil Gottel Jack A. Gilbert Dennis P. Wall Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated Microbes mSystems
author_facet	Maude M. David Christine Tataru Jena Daniels Jessey Schwartz Jessica Keating Jarrad Hampton-Marcell Neil Gottel Jack A. Gilbert Dennis P. Wall
author_sort	Maude M. David
title	Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated Microbes
title_short	Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated Microbes
title_full	Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated Microbes
title_fullStr	Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated Microbes
title_full_unstemmed	Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated Microbes
title_sort	children with autism and their typically developing siblings differ in amplicon sequence variants and predicted functions of stool-associated microbes
publisher	American Society for Microbiology
series	mSystems
issn	2379-5077
publishDate	2021-04-01
description	Autism spectrum disorder (ASD), which now affects 1 in 59 children in the United States, is known to have comorbidity with gut disorders of a variety of types; however, the link to the microbiome remains poorly characterized. Recent work has provided compelling evidence to link the gut microbiome to the autism phenotype in mouse models, but identification of specific taxa associated with autism has suffered replicability issues in humans.
url	https://journals.asm.org/doi/10.1128/mSystems.00193-20
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Children with Autism and Their Typically Developing Siblings Differ in Amplicon Sequence Variants and Predicted Functions of Stool-Associated Microbes

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