Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound.

Noninvasive and targeted gene delivery into the brain using microbubble-facilitated focused ultrasound.

Recombinant adeno-associated viral (rAAV) vectors are potentially powerful tools for gene therapy of CNS diseases, but their penetration into brain parenchyma is severely limited by the blood-brain barrier (BBB) and current delivery relies on invasive stereotactic injection. Here we evaluate the loc...

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Bibliographic Details
Main Authors: Po-Hung Hsu, Kuo-Chen Wei, Chiung-Yin Huang, Chih-Jen Wen, Tzu-Chen Yen, Chao-Lin Liu, Ya-Tin Lin, Jin-Chung Chen, Chia-Rui Shen, Hao-Li Liu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3584045?pdf=render

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