B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 a...
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2021-04-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-021-22458-9 |
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doaj-3f5d4b4a728a40e5ad631b0536b74c492021-04-18T11:13:56ZengNature Publishing GroupNature Communications2041-17232021-04-0112111710.1038/s41467-021-22458-9B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancersVinay S. Mahajan0Hamid Mattoo1Na Sun2Vinayak Viswanadham3Grace J. Yuen4Hugues Allard-Chamard5Maimuna Ahmad6Samuel J. H. Murphy7Annaiah Cariappa8Yesim Tuncay9Shiv Pillai10Ragon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardB cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 and B2 lineage-determining genes.https://doi.org/10.1038/s41467-021-22458-9 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Vinay S. Mahajan Hamid Mattoo Na Sun Vinayak Viswanadham Grace J. Yuen Hugues Allard-Chamard Maimuna Ahmad Samuel J. H. Murphy Annaiah Cariappa Yesim Tuncay Shiv Pillai |
spellingShingle |
Vinay S. Mahajan Hamid Mattoo Na Sun Vinayak Viswanadham Grace J. Yuen Hugues Allard-Chamard Maimuna Ahmad Samuel J. H. Murphy Annaiah Cariappa Yesim Tuncay Shiv Pillai B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers Nature Communications |
author_facet |
Vinay S. Mahajan Hamid Mattoo Na Sun Vinayak Viswanadham Grace J. Yuen Hugues Allard-Chamard Maimuna Ahmad Samuel J. H. Murphy Annaiah Cariappa Yesim Tuncay Shiv Pillai |
author_sort |
Vinay S. Mahajan |
title |
B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers |
title_short |
B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers |
title_full |
B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers |
title_fullStr |
B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers |
title_full_unstemmed |
B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers |
title_sort |
b1a and b2 cells are characterized by distinct cpg modification states at dnmt3a-maintained enhancers |
publisher |
Nature Publishing Group |
series |
Nature Communications |
issn |
2041-1723 |
publishDate |
2021-04-01 |
description |
B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 and B2 lineage-determining genes. |
url |
https://doi.org/10.1038/s41467-021-22458-9 |
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