B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 a...

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Main Authors:	Vinay S. Mahajan, Hamid Mattoo, Na Sun, Vinayak Viswanadham, Grace J. Yuen, Hugues Allard-Chamard, Maimuna Ahmad, Samuel J. H. Murphy, Annaiah Cariappa, Yesim Tuncay, Shiv Pillai
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-04-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/s41467-021-22458-9

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spelling	doaj-3f5d4b4a728a40e5ad631b0536b74c492021-04-18T11:13:56ZengNature Publishing GroupNature Communications2041-17232021-04-0112111710.1038/s41467-021-22458-9B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancersVinay S. Mahajan0Hamid Mattoo1Na Sun2Vinayak Viswanadham3Grace J. Yuen4Hugues Allard-Chamard5Maimuna Ahmad6Samuel J. H. Murphy7Annaiah Cariappa8Yesim Tuncay9Shiv Pillai10Ragon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardRagon Institute of MGH, MIT, and HarvardB cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 and B2 lineage-determining genes.https://doi.org/10.1038/s41467-021-22458-9
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Vinay S. Mahajan Hamid Mattoo Na Sun Vinayak Viswanadham Grace J. Yuen Hugues Allard-Chamard Maimuna Ahmad Samuel J. H. Murphy Annaiah Cariappa Yesim Tuncay Shiv Pillai
spellingShingle	Vinay S. Mahajan Hamid Mattoo Na Sun Vinayak Viswanadham Grace J. Yuen Hugues Allard-Chamard Maimuna Ahmad Samuel J. H. Murphy Annaiah Cariappa Yesim Tuncay Shiv Pillai B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers Nature Communications
author_facet	Vinay S. Mahajan Hamid Mattoo Na Sun Vinayak Viswanadham Grace J. Yuen Hugues Allard-Chamard Maimuna Ahmad Samuel J. H. Murphy Annaiah Cariappa Yesim Tuncay Shiv Pillai
author_sort	Vinay S. Mahajan
title	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_short	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_full	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_fullStr	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_full_unstemmed	B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers
title_sort	b1a and b2 cells are characterized by distinct cpg modification states at dnmt3a-maintained enhancers
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2021-04-01
description	B cell progenitors differentiate into multiple subsets with distinct functions. Here the authors analyze the epigenetic landscapes of sorted B cell subsets using multiple platforms and show that the epigenetic regulator, DNMT3A, is essential for modulating the activity of enhancers critical for B1 and B2 lineage-determining genes.
url	https://doi.org/10.1038/s41467-021-22458-9
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B1a and B2 cells are characterized by distinct CpG modification states at DNMT3A-maintained enhancers

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