Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.
Variable expression is one aspect of the heterogeneity of asthma. We aimed to define a variable pattern, which is relevant in general health epidemiological cohorts. Our objectives were to assess whether: 1) asthma patterns defined using simple asthma questions through repeated measurements could re...
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doaj-3f5e5c578dd944ed95cff8dd640be23d2021-03-03T23:18:06ZengPublic Library of Science (PLoS)PLoS ONE1932-62032013-01-0185e6509010.1371/journal.pone.0065090Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women.Margaux SanchezJean BousquetNicole Le MoualBénédicte JacqueminFrançoise Clavel-ChapelonMarc HumbertFrancine KauffmannPascale Tubert-BitterRaphaëlle VarrasoVariable expression is one aspect of the heterogeneity of asthma. We aimed to define a variable pattern, which is relevant in general health epidemiological cohorts. Our objectives were to assess whether: 1) asthma patterns defined using simple asthma questions through repeated measurements could reflect disease variability 2) these patterns may further be classified according to asthma severity/control. Among 70,428 French women, we used seven questionnaires (1992-2005) and a comprehensive reimbursement database (2004-2009) to define three reliable asthma patterns based on repeated positive answers to the ever asthma attack question: "never asthma" (n = 64,061); "inconsistent" ("yes" followed by "no", n = 3,514); "consistent" (fully consistent positive answers, n = 2,853). The "Inconsistent" pattern was related to both long-term (childhood-onset asthma with remission in adulthood) and short-term (reported asthma attack in the last 12 months, associated with asthma medication) asthma variability, showing that repeated questions are relevant markers of the variable expression of asthma. Furthermore, in this pattern, the number of positive responses (1992-2005) predicted asthma drug consumption in subsequent years, a marker of disease severity. The "Inconsistent" pattern is a phenotype that may capture the variable expression of asthma. Repeated answers, even to a simple question, are too often neglected.https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741466/pdf/?tool=EBI |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Margaux Sanchez Jean Bousquet Nicole Le Moual Bénédicte Jacquemin Françoise Clavel-Chapelon Marc Humbert Francine Kauffmann Pascale Tubert-Bitter Raphaëlle Varraso |
spellingShingle |
Margaux Sanchez Jean Bousquet Nicole Le Moual Bénédicte Jacquemin Françoise Clavel-Chapelon Marc Humbert Francine Kauffmann Pascale Tubert-Bitter Raphaëlle Varraso Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women. PLoS ONE |
author_facet |
Margaux Sanchez Jean Bousquet Nicole Le Moual Bénédicte Jacquemin Françoise Clavel-Chapelon Marc Humbert Francine Kauffmann Pascale Tubert-Bitter Raphaëlle Varraso |
author_sort |
Margaux Sanchez |
title |
Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women. |
title_short |
Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women. |
title_full |
Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women. |
title_fullStr |
Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women. |
title_full_unstemmed |
Temporal asthma patterns using repeated questionnaires over 13 years in a large French cohort of women. |
title_sort |
temporal asthma patterns using repeated questionnaires over 13 years in a large french cohort of women. |
publisher |
Public Library of Science (PLoS) |
series |
PLoS ONE |
issn |
1932-6203 |
publishDate |
2013-01-01 |
description |
Variable expression is one aspect of the heterogeneity of asthma. We aimed to define a variable pattern, which is relevant in general health epidemiological cohorts. Our objectives were to assess whether: 1) asthma patterns defined using simple asthma questions through repeated measurements could reflect disease variability 2) these patterns may further be classified according to asthma severity/control. Among 70,428 French women, we used seven questionnaires (1992-2005) and a comprehensive reimbursement database (2004-2009) to define three reliable asthma patterns based on repeated positive answers to the ever asthma attack question: "never asthma" (n = 64,061); "inconsistent" ("yes" followed by "no", n = 3,514); "consistent" (fully consistent positive answers, n = 2,853). The "Inconsistent" pattern was related to both long-term (childhood-onset asthma with remission in adulthood) and short-term (reported asthma attack in the last 12 months, associated with asthma medication) asthma variability, showing that repeated questions are relevant markers of the variable expression of asthma. Furthermore, in this pattern, the number of positive responses (1992-2005) predicted asthma drug consumption in subsequent years, a marker of disease severity. The "Inconsistent" pattern is a phenotype that may capture the variable expression of asthma. Repeated answers, even to a simple question, are too often neglected. |
url |
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23741466/pdf/?tool=EBI |
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