Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter Study
Introduction: Healthcare systems worldwide have been battling the ongoing COVID-19 pandemic. Eosinophils are multifunctional leukocytes implicated in the pathogenesis of several inflammatory processes including viral infections. We focus our study on the prognostic value of eosinopenia as a marker o...
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doaj-3f5f1f9f7ba14149888ea249d3e669702021-02-09T00:02:35ZengMDPI AGMicroorganisms2076-26072021-02-01933433410.3390/microorganisms9020334Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter StudyPierrick Le Borgne0Laure Abensur Vuillaume1Karine Alamé2François Lefebvre3Sylvie Chabrier4Lise Bérard5Pauline Haessler6Stéphane Gennai7Pascal Bilbault8Charles-Eric Lavoignet9Emergency Department, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, FranceCREMS Network (Clinical Research in Emergency Medicine and Sepsis), 67022 Wolfisheim, FranceEmergency Department, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, FranceDepartment of Public Health, University Hospital of Strasbourg, 67091 Strasbourg, FranceEmergency Department, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, FranceEmergency Department, Haguenau Hospital, 67500 Haguenau, FranceEmergency Department, Colmar Hospital, 68000 Colmar, FranceEmergency Department, Reims University Hospital, 51100 Reims, FranceEmergency Department, Hôpitaux Universitaires de Strasbourg, 67091 Strasbourg, FranceCREMS Network (Clinical Research in Emergency Medicine and Sepsis), 67022 Wolfisheim, FranceIntroduction: Healthcare systems worldwide have been battling the ongoing COVID-19 pandemic. Eosinophils are multifunctional leukocytes implicated in the pathogenesis of several inflammatory processes including viral infections. We focus our study on the prognostic value of eosinopenia as a marker of disease severity and mortality in COVID-19 patients. Methods: Between 1 March and 30 April 2020, we conducted a multicenter and retrospective study on a cohort of COVID-19 patients (moderate or severe disease) who were hospitalized after presenting to the emergency department (ED). We led our study in six major hospitals of northeast France, one of the outbreak’s epicenters in Europe. Results: We have collected data from 1035 patients, with a confirmed diagnosis of COVID-19. More than three quarters of them (76.2%) presented a moderate form of the disease, while the remaining quarter (23.8%) presented a severe form requiring admission to the intensive care unit (ICU). Mean circulating eosinophils rate, at admission, varied according to disease severity (<i>p</i> < 0.001), yet it did not differ between survivors and non-survivors (<i>p</i> = 0.306). Extreme eosinopenia (=0/mm<sup>3</sup>) was predictive of severity (aOR = 1.77, <i>p</i> = 0.009); however, it was not predictive of mortality (aOR = 0.892, <i>p</i> = 0.696). The areas under the Receiver operating characteristics (ROC) curve were, respectively, 58.5% (CI95%: 55.3–61.7%) and 51.4% (CI95%: 46.8–56.1%) for the ability of circulating eosinophil rates to predict disease severity and mortality. Conclusion: Eosinopenia is very common and often profound in cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Eosinopenia was not a useful predictor of mortality; however, undetectable eosinophils (=0/mm<sup>3</sup>) were predictive of disease severity during the initial ED management.https://www.mdpi.com/2076-2607/9/2/334COVID-19eosinophilseosinopeniaseveritymortality |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Pierrick Le Borgne Laure Abensur Vuillaume Karine Alamé François Lefebvre Sylvie Chabrier Lise Bérard Pauline Haessler Stéphane Gennai Pascal Bilbault Charles-Eric Lavoignet |
spellingShingle |
Pierrick Le Borgne Laure Abensur Vuillaume Karine Alamé François Lefebvre Sylvie Chabrier Lise Bérard Pauline Haessler Stéphane Gennai Pascal Bilbault Charles-Eric Lavoignet Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter Study Microorganisms COVID-19 eosinophils eosinopenia severity mortality |
author_facet |
Pierrick Le Borgne Laure Abensur Vuillaume Karine Alamé François Lefebvre Sylvie Chabrier Lise Bérard Pauline Haessler Stéphane Gennai Pascal Bilbault Charles-Eric Lavoignet |
author_sort |
Pierrick Le Borgne |
title |
Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter Study |
title_short |
Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter Study |
title_full |
Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter Study |
title_fullStr |
Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter Study |
title_full_unstemmed |
Do Blood Eosinophils Predict in-Hospital Mortality or Severity of Disease in SARS-CoV-2 Infection? A Retrospective Multicenter Study |
title_sort |
do blood eosinophils predict in-hospital mortality or severity of disease in sars-cov-2 infection? a retrospective multicenter study |
publisher |
MDPI AG |
series |
Microorganisms |
issn |
2076-2607 |
publishDate |
2021-02-01 |
description |
Introduction: Healthcare systems worldwide have been battling the ongoing COVID-19 pandemic. Eosinophils are multifunctional leukocytes implicated in the pathogenesis of several inflammatory processes including viral infections. We focus our study on the prognostic value of eosinopenia as a marker of disease severity and mortality in COVID-19 patients. Methods: Between 1 March and 30 April 2020, we conducted a multicenter and retrospective study on a cohort of COVID-19 patients (moderate or severe disease) who were hospitalized after presenting to the emergency department (ED). We led our study in six major hospitals of northeast France, one of the outbreak’s epicenters in Europe. Results: We have collected data from 1035 patients, with a confirmed diagnosis of COVID-19. More than three quarters of them (76.2%) presented a moderate form of the disease, while the remaining quarter (23.8%) presented a severe form requiring admission to the intensive care unit (ICU). Mean circulating eosinophils rate, at admission, varied according to disease severity (<i>p</i> < 0.001), yet it did not differ between survivors and non-survivors (<i>p</i> = 0.306). Extreme eosinopenia (=0/mm<sup>3</sup>) was predictive of severity (aOR = 1.77, <i>p</i> = 0.009); however, it was not predictive of mortality (aOR = 0.892, <i>p</i> = 0.696). The areas under the Receiver operating characteristics (ROC) curve were, respectively, 58.5% (CI95%: 55.3–61.7%) and 51.4% (CI95%: 46.8–56.1%) for the ability of circulating eosinophil rates to predict disease severity and mortality. Conclusion: Eosinopenia is very common and often profound in cases of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Eosinopenia was not a useful predictor of mortality; however, undetectable eosinophils (=0/mm<sup>3</sup>) were predictive of disease severity during the initial ED management. |
topic |
COVID-19 eosinophils eosinopenia severity mortality |
url |
https://www.mdpi.com/2076-2607/9/2/334 |
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