Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models
A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local a...
Main Authors: | , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Hindawi Limited
2018-01-01
|
Series: | Evidence-Based Complementary and Alternative Medicine |
Online Access: | http://dx.doi.org/10.1155/2018/3610494 |
id |
doaj-3f62df0a74284c689bb0a5248afefb92 |
---|---|
record_format |
Article |
spelling |
doaj-3f62df0a74284c689bb0a5248afefb922020-11-24T21:04:50ZengHindawi LimitedEvidence-Based Complementary and Alternative Medicine1741-427X1741-42882018-01-01201810.1155/2018/36104943610494Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis ModelsSong Yi Lee0Suyeong Nam1Sungyun Kim2Ja Seong Koo3In Kee Hong4Hill Kim5Sangin Han6Minji Kang7Heejung Yang8Hyun-Jong Cho9College of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of KoreaCollege of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of KoreaCollege of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of KoreaCollege of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of KoreaR&D Center, Radiant Ltd., Chuncheon, Gangwon 24398, Republic of KoreaR&D Center, Radiant Ltd., Chuncheon, Gangwon 24398, Republic of KoreaHankook Korus Pharm. Co. Ltd., Chuncheon, Gangwon 24398, Republic of KoreaHankook Korus Pharm. Co. Ltd., Chuncheon, Gangwon 24398, Republic of KoreaCollege of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of KoreaCollege of Pharmacy, Kangwon National University, Chuncheon, Gangwon 24341, Republic of KoreaA cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 (p < 0.05). The results of the hematoxylin and eosin staining of skin tissues revealed that the epidermal thickness value of the IMQ + ACE cream group was significantly lower than those of the other experimental groups (p < 0.05). The expression level of intracellular adhesion molecule-1 (ICAM-1), which indicates the leukocyte infiltration into the skin and subsequent interactions with keratinocytes, was also lower in the IMQ + ACE cream group than in the IMQ group. These results indicate that ACE cream formulation could be used safely and conveniently for psoriasis treatment.http://dx.doi.org/10.1155/2018/3610494 |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Song Yi Lee Suyeong Nam Sungyun Kim Ja Seong Koo In Kee Hong Hill Kim Sangin Han Minji Kang Heejung Yang Hyun-Jong Cho |
spellingShingle |
Song Yi Lee Suyeong Nam Sungyun Kim Ja Seong Koo In Kee Hong Hill Kim Sangin Han Minji Kang Heejung Yang Hyun-Jong Cho Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models Evidence-Based Complementary and Alternative Medicine |
author_facet |
Song Yi Lee Suyeong Nam Sungyun Kim Ja Seong Koo In Kee Hong Hill Kim Sangin Han Minji Kang Heejung Yang Hyun-Jong Cho |
author_sort |
Song Yi Lee |
title |
Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_short |
Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_full |
Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_fullStr |
Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_full_unstemmed |
Therapeutic Efficacies of Artemisia capillaris Extract Cream Formulation in Imiquimod-Induced Psoriasis Models |
title_sort |
therapeutic efficacies of artemisia capillaris extract cream formulation in imiquimod-induced psoriasis models |
publisher |
Hindawi Limited |
series |
Evidence-Based Complementary and Alternative Medicine |
issn |
1741-427X 1741-4288 |
publishDate |
2018-01-01 |
description |
A cream formulation containing Artemisia capillaris (AC) extract (ACE) was developed for psoriasis therapy. Although ACE can be dissolved in organic solvents, its topical application is restricted because of toxicities. Therefore, a cream formulation was developed for the convenient and safe local application of ACE on skin lesions. The antipsoriatic properties of the ACE cream were evaluated using an imiquimod- (IMQ-) induced psoriasis-like mouse model. In psoriasis-like mouse models, the cumulative score (redness, thickness, and scaling) of the IMQ + ACE cream group was significantly lower than those of the other groups on day 4 (p < 0.05). The results of the hematoxylin and eosin staining of skin tissues revealed that the epidermal thickness value of the IMQ + ACE cream group was significantly lower than those of the other experimental groups (p < 0.05). The expression level of intracellular adhesion molecule-1 (ICAM-1), which indicates the leukocyte infiltration into the skin and subsequent interactions with keratinocytes, was also lower in the IMQ + ACE cream group than in the IMQ group. These results indicate that ACE cream formulation could be used safely and conveniently for psoriasis treatment. |
url |
http://dx.doi.org/10.1155/2018/3610494 |
work_keys_str_mv |
AT songyilee therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT suyeongnam therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT sungyunkim therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT jaseongkoo therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT inkeehong therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT hillkim therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT sanginhan therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT minjikang therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT heejungyang therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels AT hyunjongcho therapeuticefficaciesofartemisiacapillarisextractcreamformulationinimiquimodinducedpsoriasismodels |
_version_ |
1716769586378964992 |