Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure

Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure

Takaaki Furihata et al. report a new mouse model with heart-specific deletion of the mitochondrial protein, mitoNEET. Their results suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.

Bibliographic Details
Main Authors: Takaaki Furihata, Shingo Takada, Naoya Kakutani, Satoshi Maekawa, Masaya Tsuda, Junichi Matsumoto, Wataru Mizushima, Arata Fukushima, Takashi Yokota, Nobuyuki Enzan, Shouji Matsushima, Haruka Handa, Yoshizuki Fumoto, Junko Nio-Kobayashi, Toshihiko Iwanaga, Shinya Tanaka, Hiroyuki Tsutsui, Hisataka Sabe, Shintaro Kinugawa
Format: Article
Language:English
Published: Nature Publishing Group 2021-01-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-021-01675-4
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spelling doaj-3f63983eae254d919bb87225d2d4c10c2021-01-31T16:16:26ZengNature Publishing GroupCommunications Biology2399-36422021-01-014111110.1038/s42003-021-01675-4Cardiac-specific loss of mitoNEET expression is linked with age-related heart failureTakaaki Furihata0Shingo Takada1Naoya Kakutani2Satoshi Maekawa3Masaya Tsuda4Junichi Matsumoto5Wataru Mizushima6Arata Fukushima7Takashi Yokota8Nobuyuki Enzan9Shouji Matsushima10Haruka Handa11Yoshizuki Fumoto12Junko Nio-Kobayashi13Toshihiko Iwanaga14Shinya Tanaka15Hiroyuki Tsutsui16Hisataka Sabe17Shintaro Kinugawa18Department of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Kyushu University Graduate School of Medical SciencesDepartment of Cardiovascular Medicine, Kyushu University Graduate School of Medical SciencesDepartment of Molecular Biology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Molecular Biology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityLaboratory of Histology and Cytology, Department of Anatomy, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityLaboratory of Histology and Cytology, Department of Anatomy, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cancer Pathology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Kyushu University Graduate School of Medical SciencesDepartment of Molecular Biology, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityDepartment of Cardiovascular Medicine, Faculty of Medicine and Graduate School of Medicine, Hokkaido UniversityTakaaki Furihata et al. report a new mouse model with heart-specific deletion of the mitochondrial protein, mitoNEET. Their results suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.https://doi.org/10.1038/s42003-021-01675-4
collection DOAJ
language English
format Article
sources DOAJ
author Takaaki Furihata
Shingo Takada
Naoya Kakutani
Satoshi Maekawa
Masaya Tsuda
Junichi Matsumoto
Wataru Mizushima
Arata Fukushima
Takashi Yokota
Nobuyuki Enzan
Shouji Matsushima
Haruka Handa
Yoshizuki Fumoto
Junko Nio-Kobayashi
Toshihiko Iwanaga
Shinya Tanaka
Hiroyuki Tsutsui
Hisataka Sabe
Shintaro Kinugawa
spellingShingle Takaaki Furihata
Shingo Takada
Naoya Kakutani
Satoshi Maekawa
Masaya Tsuda
Junichi Matsumoto
Wataru Mizushima
Arata Fukushima
Takashi Yokota
Nobuyuki Enzan
Shouji Matsushima
Haruka Handa
Yoshizuki Fumoto
Junko Nio-Kobayashi
Toshihiko Iwanaga
Shinya Tanaka
Hiroyuki Tsutsui
Hisataka Sabe
Shintaro Kinugawa
Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
Communications Biology
author_facet Takaaki Furihata
Shingo Takada
Naoya Kakutani
Satoshi Maekawa
Masaya Tsuda
Junichi Matsumoto
Wataru Mizushima
Arata Fukushima
Takashi Yokota
Nobuyuki Enzan
Shouji Matsushima
Haruka Handa
Yoshizuki Fumoto
Junko Nio-Kobayashi
Toshihiko Iwanaga
Shinya Tanaka
Hiroyuki Tsutsui
Hisataka Sabe
Shintaro Kinugawa
author_sort Takaaki Furihata
title Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
title_short Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
title_full Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
title_fullStr Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
title_full_unstemmed Cardiac-specific loss of mitoNEET expression is linked with age-related heart failure
title_sort cardiac-specific loss of mitoneet expression is linked with age-related heart failure
publisher Nature Publishing Group
series Communications Biology
issn 2399-3642
publishDate 2021-01-01
description Takaaki Furihata et al. report a new mouse model with heart-specific deletion of the mitochondrial protein, mitoNEET. Their results suggest that loss of mitoNEET expression may contribute to age-associated heart failure in older adults.
url https://doi.org/10.1038/s42003-021-01675-4
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