A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development

A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development

NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.

Bibliographic Details
Main Authors: Stefan Klein-Hessling, Ronald Rudolf, Khalid Muhammad, Klaus-Peter Knobeloch, Muhammad Ahmad Maqbool, Pierre Cauchy, Jean-Christophe Andrau, Andris Avots, Claudio Talora, Volker Ellenrieder, Isabella Screpanti, Edgar Serfling, Amiya Kumar Patra
Format: Article
Language:English
Published: Nature Publishing Group 2016-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/ncomms11841
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spelling doaj-3f649647fbdd4d0799d4dc0597425c492021-05-11T11:20:25ZengNature Publishing GroupNature Communications2041-17232016-06-017111410.1038/ncomms11841A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia developmentStefan Klein-Hessling0Ronald Rudolf1Khalid Muhammad2Klaus-Peter Knobeloch3Muhammad Ahmad Maqbool4Pierre Cauchy5Jean-Christophe Andrau6Andris Avots7Claudio Talora8Volker Ellenrieder9Isabella Screpanti10Edgar Serfling11Amiya Kumar Patra12Department of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Pathology, Institute of Neuropathology, University Clinic FreiburgInstitute de Génétique Moléculaire de Montpellier (IGMM)Institute of Biomedical Research, College of Medical and Dental Sciences, University of BirminghamInstitute de Génétique Moléculaire de Montpellier (IGMM)Department of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Molecular Medicine, Laboratory of Molecular Pathology, Sapienza University of RomeDepartment of Gastroenterology II, University of GoettingenDepartment of Molecular Medicine, Laboratory of Molecular Pathology, Sapienza University of RomeDepartment of Molecular Pathology, Institute for Pathology, University of WuerzburgDepartment of Molecular Pathology, Institute for Pathology, University of WuerzburgNFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.https://doi.org/10.1038/ncomms11841
collection DOAJ
language English
format Article
sources DOAJ
author Stefan Klein-Hessling
Ronald Rudolf
Khalid Muhammad
Klaus-Peter Knobeloch
Muhammad Ahmad Maqbool
Pierre Cauchy
Jean-Christophe Andrau
Andris Avots
Claudio Talora
Volker Ellenrieder
Isabella Screpanti
Edgar Serfling
Amiya Kumar Patra
spellingShingle Stefan Klein-Hessling
Ronald Rudolf
Khalid Muhammad
Klaus-Peter Knobeloch
Muhammad Ahmad Maqbool
Pierre Cauchy
Jean-Christophe Andrau
Andris Avots
Claudio Talora
Volker Ellenrieder
Isabella Screpanti
Edgar Serfling
Amiya Kumar Patra
A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
Nature Communications
author_facet Stefan Klein-Hessling
Ronald Rudolf
Khalid Muhammad
Klaus-Peter Knobeloch
Muhammad Ahmad Maqbool
Pierre Cauchy
Jean-Christophe Andrau
Andris Avots
Claudio Talora
Volker Ellenrieder
Isabella Screpanti
Edgar Serfling
Amiya Kumar Patra
author_sort Stefan Klein-Hessling
title A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
title_short A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
title_full A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
title_fullStr A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
title_full_unstemmed A threshold level of NFATc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
title_sort threshold level of nfatc1 activity facilitates thymocyte differentiation and opposes notch-driven leukaemia development
publisher Nature Publishing Group
series Nature Communications
issn 2041-1723
publishDate 2016-06-01
description NFATc1 orchestrates thymocyte development. Here the authors show that NFATc1 expression is regulated by distinct promoters during thymocyte differentiation, and by conditional deletion of individual promoters in mice they define their specific roles in the control of T-cell development by NFATc1.
url https://doi.org/10.1038/ncomms11841
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