Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome
ABSTRACT Purpose: We aimed to compare the thickness of anterior sclera, corneal layers, and pre-ocular tear film between patients with primary Sjögren's syndrome and healthy individuals. Methods: Fifty-one patients with primary Sjögren's syndrome and 41 healthy control participants were...
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2019-04-01
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doaj-3f681833ba5c4b69a21d20ff6531f3c72020-11-25T02:56:09ZengConselho Brasileiro de OftalmologiaArquivos Brasileiros de Oftalmologia1678-29252019-04-01010.5935/0004-2749.20190054S0004-27492019005006101Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndromeGökhan PekelMurat TaşçıAlperen BaharEvre PekelEbru Nevin ÇetinÇiğdem MartinVeli ÇobankaraABSTRACT Purpose: We aimed to compare the thickness of anterior sclera, corneal layers, and pre-ocular tear film between patients with primary Sjögren's syndrome and healthy individuals. Methods: Fifty-one patients with primary Sjögren's syndrome and 41 healthy control participants were recruited in this cross-sectional and comparative study. The thickness of the pre-ocular tear film, corneal epithelium, Bowman's layer, stroma, Descemet's membrane, and endothelium were measured on the corneal apex. Anterior scleral thickness was measured at distances of 1 mm and 3 mm from the limbus. The anterior segment module of spectral-domain optical coherence tomography was used to measure thicknesses of pre-ocular tear film, corneal layers, and anterior sclera. Results: Tear film thickness, Schirmer's test, and tear break up time values were significantly lower in the Sjögren's disease group than in the healthy controls (p<0.05). The thickness measurements of corneal layers and sclera were similar between the groups. Tear film thickness was moderately correlated with the Schirmer's test results (r=0.34, p=0.001), but there was no correlation between the Schirmer's test results and tear break up time (r=0.18, p=0.09). Conclusions: Pre-ocular tear film, as measured by anterior segment optical coherence tomography, was thinner in patients with primary Sjögren's syndrome than in the healthy controls. The thicknesses of corneal layers and anterior sclera were similar between the groups.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019005006101&lng=en&tlng=enEscleraSíndrome de Sjogren-LarssonSegmento anterior do olhoTomografia de coerência ópticaEstudo comparativo |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Gökhan Pekel Murat Taşçı Alperen Bahar Evre Pekel Ebru Nevin Çetin Çiğdem Martin Veli Çobankara |
spellingShingle |
Gökhan Pekel Murat Taşçı Alperen Bahar Evre Pekel Ebru Nevin Çetin Çiğdem Martin Veli Çobankara Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome Arquivos Brasileiros de Oftalmologia Esclera Síndrome de Sjogren-Larsson Segmento anterior do olho Tomografia de coerência óptica Estudo comparativo |
author_facet |
Gökhan Pekel Murat Taşçı Alperen Bahar Evre Pekel Ebru Nevin Çetin Çiğdem Martin Veli Çobankara |
author_sort |
Gökhan Pekel |
title |
Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome |
title_short |
Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome |
title_full |
Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome |
title_fullStr |
Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome |
title_full_unstemmed |
Evaluation of corneal layers and anterior sclera in patients with primary Sjögren's syndrome |
title_sort |
evaluation of corneal layers and anterior sclera in patients with primary sjögren's syndrome |
publisher |
Conselho Brasileiro de Oftalmologia |
series |
Arquivos Brasileiros de Oftalmologia |
issn |
1678-2925 |
publishDate |
2019-04-01 |
description |
ABSTRACT Purpose: We aimed to compare the thickness of anterior sclera, corneal layers, and pre-ocular tear film between patients with primary Sjögren's syndrome and healthy individuals. Methods: Fifty-one patients with primary Sjögren's syndrome and 41 healthy control participants were recruited in this cross-sectional and comparative study. The thickness of the pre-ocular tear film, corneal epithelium, Bowman's layer, stroma, Descemet's membrane, and endothelium were measured on the corneal apex. Anterior scleral thickness was measured at distances of 1 mm and 3 mm from the limbus. The anterior segment module of spectral-domain optical coherence tomography was used to measure thicknesses of pre-ocular tear film, corneal layers, and anterior sclera. Results: Tear film thickness, Schirmer's test, and tear break up time values were significantly lower in the Sjögren's disease group than in the healthy controls (p<0.05). The thickness measurements of corneal layers and sclera were similar between the groups. Tear film thickness was moderately correlated with the Schirmer's test results (r=0.34, p=0.001), but there was no correlation between the Schirmer's test results and tear break up time (r=0.18, p=0.09). Conclusions: Pre-ocular tear film, as measured by anterior segment optical coherence tomography, was thinner in patients with primary Sjögren's syndrome than in the healthy controls. The thicknesses of corneal layers and anterior sclera were similar between the groups. |
topic |
Esclera Síndrome de Sjogren-Larsson Segmento anterior do olho Tomografia de coerência óptica Estudo comparativo |
url |
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0004-27492019005006101&lng=en&tlng=en |
work_keys_str_mv |
AT gokhanpekel evaluationofcorneallayersandanteriorsclerainpatientswithprimarysjogrenssyndrome AT murattascı evaluationofcorneallayersandanteriorsclerainpatientswithprimarysjogrenssyndrome AT alperenbahar evaluationofcorneallayersandanteriorsclerainpatientswithprimarysjogrenssyndrome AT evrepekel evaluationofcorneallayersandanteriorsclerainpatientswithprimarysjogrenssyndrome AT ebrunevincetin evaluationofcorneallayersandanteriorsclerainpatientswithprimarysjogrenssyndrome AT cigdemmartin evaluationofcorneallayersandanteriorsclerainpatientswithprimarysjogrenssyndrome AT velicobankara evaluationofcorneallayersandanteriorsclerainpatientswithprimarysjogrenssyndrome |
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