Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort
There is widespread metabolic disruption in women upon becoming pregnant. South Asians (SA) compared to White Europeans (WE) have more fat mass and are more insulin-resistant at a given body mass index (BMI). Whether these are reflected in other gestational metabolomic differences is unclear. Our ai...
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doaj-3f6f33a6968e4ee4adf18766fdeb923a2020-11-24T21:59:50ZengMDPI AGMetabolites2218-19892019-09-019919010.3390/metabo9090190metabo9090190Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford CohortKurt Taylor0Diana L. Santos Ferreira1Jane West2Tiffany Yang3Massimo Caputo4Deborah A. Lawlor5Population Health Science, Bristol Medical School, Bristol BS8 2BN, UKPopulation Health Science, Bristol Medical School, Bristol BS8 2BN, UKBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford BD9 6RJ, UKBradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford BD9 6RJ, UKTranslational Science, Bristol Medical School, Bristol BS2 8DZ, UKPopulation Health Science, Bristol Medical School, Bristol BS8 2BN, UKThere is widespread metabolic disruption in women upon becoming pregnant. South Asians (SA) compared to White Europeans (WE) have more fat mass and are more insulin-resistant at a given body mass index (BMI). Whether these are reflected in other gestational metabolomic differences is unclear. Our aim was to compare gestational metabolic profiles and their determinants between WE and SA women. We used data from a United Kingdom (UK) cohort to compare metabolic profiles and associations of maternal age, education, parity, height, BMI, tricep skinfold thickness, gestational diabetes (GD), pre-eclampsia, and gestational hypertension with 156 metabolic measurements in WE (<i>n</i> = 4072) and SA (<i>n</i> = 4702) women. Metabolic profiles, measured in fasting serum taken between 26−28 weeks gestation, were quantified by nuclear magnetic resonance. Distributions of most metabolic measures differed by ethnicity. WE women had higher levels of most lipoprotein subclasses, cholesterol, glycerides and phospholipids, monosaturated fatty acids, and creatinine but lower levels of glucose, linoleic acid, omega-6 and polyunsaturated fatty acids, and most amino acids. Higher BMI and having GD were associated with higher levels of several lipoprotein subclasses, triglycerides, and other metabolites, mostly with stronger associations in WEs. We have shown differences in gestational metabolic profiles between WE and SA women and demonstrated that associations of exposures with these metabolites differ by ethnicity.https://www.mdpi.com/2218-1989/9/9/190pregnancyethnicityserummetabolomicscardiometabolic profilebirth cohortBorn in Bradford |
collection |
DOAJ |
language |
English |
format |
Article |
sources |
DOAJ |
author |
Kurt Taylor Diana L. Santos Ferreira Jane West Tiffany Yang Massimo Caputo Deborah A. Lawlor |
spellingShingle |
Kurt Taylor Diana L. Santos Ferreira Jane West Tiffany Yang Massimo Caputo Deborah A. Lawlor Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort Metabolites pregnancy ethnicity serum metabolomics cardiometabolic profile birth cohort Born in Bradford |
author_facet |
Kurt Taylor Diana L. Santos Ferreira Jane West Tiffany Yang Massimo Caputo Deborah A. Lawlor |
author_sort |
Kurt Taylor |
title |
Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort |
title_short |
Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort |
title_full |
Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort |
title_fullStr |
Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort |
title_full_unstemmed |
Differences in Pregnancy Metabolic Profiles and Their Determinants between White European and South Asian Women: Findings from the Born in Bradford Cohort |
title_sort |
differences in pregnancy metabolic profiles and their determinants between white european and south asian women: findings from the born in bradford cohort |
publisher |
MDPI AG |
series |
Metabolites |
issn |
2218-1989 |
publishDate |
2019-09-01 |
description |
There is widespread metabolic disruption in women upon becoming pregnant. South Asians (SA) compared to White Europeans (WE) have more fat mass and are more insulin-resistant at a given body mass index (BMI). Whether these are reflected in other gestational metabolomic differences is unclear. Our aim was to compare gestational metabolic profiles and their determinants between WE and SA women. We used data from a United Kingdom (UK) cohort to compare metabolic profiles and associations of maternal age, education, parity, height, BMI, tricep skinfold thickness, gestational diabetes (GD), pre-eclampsia, and gestational hypertension with 156 metabolic measurements in WE (<i>n</i> = 4072) and SA (<i>n</i> = 4702) women. Metabolic profiles, measured in fasting serum taken between 26−28 weeks gestation, were quantified by nuclear magnetic resonance. Distributions of most metabolic measures differed by ethnicity. WE women had higher levels of most lipoprotein subclasses, cholesterol, glycerides and phospholipids, monosaturated fatty acids, and creatinine but lower levels of glucose, linoleic acid, omega-6 and polyunsaturated fatty acids, and most amino acids. Higher BMI and having GD were associated with higher levels of several lipoprotein subclasses, triglycerides, and other metabolites, mostly with stronger associations in WEs. We have shown differences in gestational metabolic profiles between WE and SA women and demonstrated that associations of exposures with these metabolites differ by ethnicity. |
topic |
pregnancy ethnicity serum metabolomics cardiometabolic profile birth cohort Born in Bradford |
url |
https://www.mdpi.com/2218-1989/9/9/190 |
work_keys_str_mv |
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