Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases

Differential Action of Connexin Hemichannel and Pannexin Channel Therapeutics for Potential Treatment of Retinal Diseases

Dysregulation of retinal function in the early stages of light-induced retinal degeneration involves pannexins and connexins. These two types of proteins may contribute to channels that release ATP, leading to activation of the inflammasome pathway, spread of inflammation and retinal dysfunction. Ho...

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Bibliographic Details
Main Authors: Mohd N. Mat Nor, Ilva D. Rupenthal, Colin R. Green, Monica L. Acosta
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:International Journal of Molecular Sciences
Subjects:
retina
light damage
connexin43
pannexin
tonabersat
probenecid
Online Access:https://www.mdpi.com/1422-0067/22/4/1755

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